Báo cáo y học: "Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13" docx
Báo cáo y học: "Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13" docx
... analpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in carti-lage chondrocytes. ... goodquality of life. Consequently, the challenge of improving the ACL: anterior cruciate ligament; ASU: avocado/soybean unsaponifiables; iNOS: inducible nitric oxide synthase; MMP: matrix metalloproteinase; ... An in vivo study with N-iminoethyl-L-lysine, a potent and selective iNOS inhibitor [52], demonstrated its therapeuticeffectiveness in reducing the progression of experimental OA in the ACL dog...
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Báo cáo y học: "Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study" doc
... AG18393. The study sponsor was not involved in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the paper ... by chondrocytes, synovial cells, and other cells of the skeleton. Its synthesis is increased in chondrocytes and in synovial cells when activated by proin-flammatory cytokines [37]. Preliminary ... degradation. A secondary and more indirect indica-tion is cartilage matrix synthesis. The amount of synthesis in relation to degradation may prove of great importance in deter-mining disease...
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Báo cáo y học: "Positioning Effects of KillerRed inside of Cells correlate with DNA Strand Breaks after Activation with Visible Light"
... protein and is part of the nuclear chromatin whereas the second half of the fusion protein, the KRED produces highly reactive radicals inducing damages [31] in the sur-rounding proteins and ... to mark the broken DNA and to analyse the type and number of genes involved.We also like to analyse the genes present in the periphery of the nuclei in different phases of the cell cycle. Acknowledgements ... part and shown in Figure 1. The cellular chromatin and thereby the DNA is exposed to highly reactive ROS which induce single strand breaks in the DNA. In cells, generally, these toxic effects...
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Tài liệu Báo cáo Y học: Differential effects of arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils pot
... synthetase, inhibition of CoA-IT results in anincrease in free AA and a corresponding build-up of AA in triacylglycerols that can be prevented by co-incubation of cells with CoA-synthetase inhibitors ... (1973) The enzymicincorporation of arachidonic acid into ether-containing choline and ethanolamine phosphoglycerides by deacylation-acylationreactions. Biochim. Biophys. Acta 326, 26–33.51. Yamashita, ... radioactivity imaging system (Washington, DC,USA) and the amount of radioactivity migrating with PAFwas determined by zonal scraping, followed by liquidscintillation counting.Determination of 5-LO...
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Báo cáo Y học: Tyrosine sulfation and N-glycosylation of human heparin cofactor II from plasma and recombinant Chinese hamster ovary cells and their effects on heparin binding pot
... post-translationalmodifications on heparin binding, recombinant CHO cellswere treated with inhibitors of tyrosine s ulfation and N-glycosylation under conditions that allowed partial inhibition of these modifications. ... medium containing the same concentration of the glycosylation inhibitor w as added. Three days later, the conditioned medium was harvested and inspected byWestern blotting for the presence of HCII ... 1997) Effect of individual carbohydrate chains of recombinant a ntithrom bin o n h eparin affi nity and on the gene r-ation of g lycoforms differing in heparin affinity. Arch. Biochem.Biophys. 341 ,...
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Báo cáo khoa học: Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation pdf
... fragmentation (Fig. 7B). On the basis of the intensity of bands, the protective activity follows the sequence of EM1 > GSH > EM2. Inhibition of REM by EM1 and EM2Using the same sample solutions ... spectroscopy since the primary peroxidationFig. 8. Inhibition of the increase in REM of LDL during the Cu2+-induced (A) or AAPH-initiated (B) peroxidation of LDL by endo-morphins and GSH. LDL ... follows the same sequence in spite of the activity being monitored by conjugated dieneformation or by TBARS production, and in spite of the peroxidation being initiated by Cu2+or by peroxylradicals...
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Báo cáo khoa học: "Protective effects of N-acetylcysteine and selenium against doxorubicin toxicity in rats" docx
... class="bi x0 y0 w1 h3" alt="" ...
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
... of glycosaminoglycan release and nitric oxide production, and induction of fibrogenesis and muscle edema. In addition,induction of chondrogenesis within the synovial lining wasobserved. These results ... effects of IL-1β on matrix metabolism [21,25]. Inhibition of white blood cell infiltration and elevation of nitric oxide synthesisTo determine whether TGF-β1 expression could inhibit the mild inflammation ... inflammation induced by intra-articular injection of high doses of adenovirus or the severe inflammationoccurring in the AIA model, the levels of white bloodleukocytic infiltrate in the synovial...
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Báo cáo y học: "Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro" pps
... grey) and M2139 (dark grey) over the course of 21 days. (b) The number of empty chondrons expressed as a percentage of the total number of chondrons, indicating the loss of chondrocyte from the ... hypertrophy and there was a measurable increase in the proportion of empty chondrons. Notably, the non-arthritogenic mAb CIIF4induced none of these changes. To quantify changes in the explant ... 6a–f and 7a–c; Table 1). The concentration of proteogly-cans from the middle of the tissue, beyond the penetration of the mAb, did not differ from the controls, as judged by the height of the...
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Báo cáo y học: " Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis" pptx
... RT-PCR of the enzymes involved in the synthesis of these mediators (cyclooxygenase-2 (COX-2) and inducibleFigure 1Cytokine circulating levels in mice at the end of treatment in the collagen-induced ... isexpressed by a variety of cell types involved in RA, includingactivated T cells and synoviocytes [8]. These cells, in the pres-ence of cytokines like TNFα and macrophage colony stimulat-ing factor, ... accompanied by infiltration of the synovial membrane and synovial cavity as well as by extensivelocal bone and cartilage destruction and loss of bone mineraldensity [7]. This condition in mice mimics...
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