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Báo cáo y học: "erum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis" doc

Báo cáo y học:

Báo cáo y học: "erum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis" doc

... not for citation purposes)Vol 11 No 2Research articleSerum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, ... TE: Binding of receptor for advanced glycation end products (RAGE) lig-ands is not sufficient to induce inflammatory signals: lack of activity of endotoxin-free albumin-derived advanced glycation end ... werecorrelated in RA patients. S100A9 levels were associated with body mass index (BMI), and with serum levels of S100A8 and S100A12. S100A8 levels were associated with serum levels of S100A9, presence of...
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Báo cáo y học: "levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control" docx

... and in patients with degenerative/traumatic joint diseases (non-inflammatory joint disease [NID] )Levels of soluble receptor for advanced glycation end products (soluble RAGE) in blood and synovial ... IL = interleukin; NID = non-inflammatory joint disease; RA = rheumatoid arthritis; RAGE = receptor for advanced glycation end products; sRAGE = soluble receptor for advanced glycation end products. Arthritis ... that soluble RAGE may block theligand–RAGE interaction on the cell surface by directly bind-ing leukocyte β2-integrin Mac-1 and thereby decreasing influx of inflammatory cells into the joint...
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Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx

Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx

... inaccuratepositioning of the interacting groups.The contact area of the distamycin amidinium end wasinvestigated by evaluating the hydrogen positions and interaction energy terms for the interactions ... amidinium end and bases A15, T8 and G9, and (B) theformamide end and bases C4 and G19. Intermolecular geometry frozen according to the crystal data. Drug fragment atoms are yellow.2874 K. Uytterhoeven ... and are kept together bydipole–dipole interactions between stacking pyrrole rings and amide bonds. Each drug hydrogen-bonds with thebases of only one DNA strand and stacks with the sugarrings.We...
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Báo cáo y học: "Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis" potx

... amyloid and advanced glycation end products (AGEs)[15]. AGEs are the products of nonenzymatic glycation and oxidation of proteins that form with aging, diabetes and renalfailure, and at sites of inflammation ... com-mencing a variety of antirheumatic drugs rather than atbaseline. In RA, proinflammatory ligands of the RAGE, includingS100A12 and HMGB1, are reported to be expressed at high levels, levels of soluble ... properly cited.AbstractPatients with rheumatoid arthritis (RA) are at risk of excessmortality, predominantly owing to cardiovascular (CV) events.The receptor for advanced glycation end products...
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Tài liệu Báo cáo Y học: Evidence that a eukaryotic-type serine/threonine protein kinase from Mycobacterium tuberculosis regulates morphological changes associated with cell division docx

Tài liệu Báo cáo Y học: Evidence that a eukaryotic-type serine/threonine protein kinase from Mycobacterium tuberculosis regulates morphological changes associated with cell division docx

... compare lanes 2 and 3). All these induced proteins werefound in the soluble fraction (Fig. 1A, lane 4). Subsequentaffinity purification of the soluble proteins revealed binding of only t he one of ... ability of the fusion proteinwas monitored b y incubating it with [c-32P]ATP in t hepresence of Mn2+, f ollowed by separation of reaction products by SDS/PAGE. Finally, the labelled protein ... division.Finally, our study in a heterologous setting has shown theinvolvement of PknA in cell shape regulation; it is the firstreport describing the functionality of any eukaryotic-typeSer/Thr kinase...
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Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"

... measurement of serum thrombopoietin and expression of megakaryocyte c-mlp with clinical and laboratory correlates for myelofibrosis with myeloid metaplasia. Eur J Haematol 2002;68:175-9. 27. Yan ... R, Takayama T, Kato J, Yamauchi N, Ko-gawa K, Sakamaki S, Hirayama Y, Kohda K, Niitsu Y. Involve-ment of transforming growth factor-beta and thrombopoietin in the pathogenesis of myelodysplastic ... Lacey D, Hill D, Chen Y, Fletcher F, Hawley RG, McNiece IK A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone...
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Báo cáo y học: "Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus" ppsx

... indices are indirect measures of brain inflammation. In contrast to a mul-titude of studies analyzing local inflammatory response in NPSLE, the evaluation of neuronal damage and the forma-tion of ... study was to measure the levels of brain-specific proteins directly or indirectly related todementia disorders (tau, Aβ42, APP and TGF-β) in theCSF of SLE patients with and without CNS involvement, and ... 1Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein but increases of intrathecal axonal degradation products and TGF-β in patients with cerebral lupus. (a) Cerebrospinal...
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Báo cáo y học: "Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus" potx

... consumption of CRP by ICs [35]. With this in mind we find the high fre-quency (4 of 4) of anti-CRP in patients with ongoingkidney involvement interesting, given the pathogeneticimplications of ICs in ... G, Symmons D, Zoma A: Thedevelopment and initial validation of the Systemic LupusInternational Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythemato-sus. ... high levels at thetime-point of flare. Both individually and collectively, signifi-cant correlations were found between anti-CRP levels and several clinical and laboratory disease activity measures,namely...
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Báo cáo y học: "Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis" docx

... Vitamin D binding protein (Gc-globulin).Endocr Rev 1989, 10:294-307.18. Lind SE, Smith DB, Janmey PA, Stossel TP: Role of plasma gel-solin and the vitamin D-binding protein in clearing actin ... clearing actin from synovial joints of rheumatoid arthritis patients with acute joint effusion. (1) pGSN and other proteins from blood enter the inflamed synovial joint space freely due to increased ... of plasma gelsolin (pGSN) function in clearing actin from synovial joints of rheumatoid arthritis patients with acute joint effusionProposed model of plasma gelsolin (pGSN) function in clearing...
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Báo cáo y học: "Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment" ppt

... significantly [31]. Increased serum levels of BALPmight reflect not only new bone formation in repair tissue of inflammatory lesions in AS but also a more general increase of bone mineral density in ... process.IntroductionAnkylosing spondylitis (AS) is a chronic inflammatory disease with inflammation in the spine which can lead to bone ero-sions, new bone formation, and ankylosis in the spine. Inflam-mation ... be highly effective for the improvement of signs, symptoms, and function and thereduction of both C-reactive protein (CRP) and active inflam-mation in the sacroiliac joints and the spine as...
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