... 50-70% in the stomach, 25-30% in the small intestine, 5-10% in the colon-rectum, < 5% in th e esophagus, the remainingmay a rise within the omentum or within the peritonellayers (Extra-Gastro-intestinal ... oneEGIST), one of those requiring a second line therapy. DiscussionGISTs originate from ICC or from mesenchymal stemcells throughout the gastro intestinal tract, or in extra-gastrointestinal structures. ... 19.2% of patients had an incidental diag-nosis of GIST.Most common symptoms are abdominal, mainly epi-gastric pain (usually a late symptom due compression of nearby organs) and gastrointestinal...