... give treatment recom-mendations, we have systematically reviewed the results of both chemotherapy alone and combined with radia-tion treatment for newly diagnosed brain metastases from solid ... withwhole -brain radiotherapy for brain metastases. J Clin Oncol1998, 16:3563-3569.4. Cho KH, Hall WA, Gerbi BJ, Higgins PD, Bohen M, Clark HB: Patientselection criteria for the treatment of brain metastases ... because of several facts that are specific for brain tumors [40]. First of all, the intact BBB preventsaccess to the brain for several compounds. Even in areas of BBB disturbance, the effects of...