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Báo cáo khoa học: "On the dosimetric impact of inhomogeneity management in the Acuros XB algorithm for breast treatment" pot

Báo cáo khoa học:

Báo cáo khoa học: "On the dosimetric impact of inhomogeneity management in the Acuros XB algorithm for breast treatment" pot

... visible in the common prac-tice of inspecting DVH. The same effect is the difference of dose calculated in the muscle tissue of the breast, andagain not visible in common DVH analysis being the muscle ... and, for the subject o f the study, the main point is focussed to the capability, for Acuros XB, to manage elementalcompositions of some predefined human tissues, andtherefore to calculate the ... RESEARC H Open AccessOn the dosimetric impact of inhomogeneity management in the Acuros XB algorithm for breast treatmentAntonella Fogliata*, Giorgia Nicolini, Alessandro Clivio, Eugenio...
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Báo cáo khoa học: Acute intermittent porphyria – impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties pdf

Báo cáo khoa học: Acute intermittent porphyria – impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties pdf

... to the wild-type) and to a reduction of thermal stability. It islikely that the introduction of the positive charge of the lysine amino group attracts the carboxyl of Glu135 and brings the ... results only in a subtle change: the shortening of the bridge length by one methylenegroup. The abolition of the activity demonstrates the importance of an exact geometry in the interior of the enzyme.c.771 ... andC-domains are shown in silver, blue and green, respectively; the positions of the mutated amino acids are indicated in red; and the position of the last amino acid before the frameshift is shown in black....
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Báo cáo khoa học: Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis potx

Báo cáo khoa học: Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis potx

... important in the literature and haveroles assigned [12–18,20]: *, CTP-binding residue of the P-loop; (*), CTP-binding residue; ^, Neu5Ac-binding residue; #, Neu5Ac-bindingresidue forming part of the ... al. [14] in the related enzyme, L-CKS,because mutation would interfere with both Neu5Acbinding as well as playing a role in the re-orientation of Mg2+binding during the re-opening of the activesite ... concentrations in the presence or absence of 0.2 mm dithiothreitol.Effect of Mg2+concentration The effect of an increase in the concentration of Mg2+wasdetermined by measuring the rate of the reaction...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

... hydration of the protein domain is the driving force of protein stabiliza-tion or folding [3,4]. Furthermore, the effect of osmolytes on the functional activity of an enzyme hasalso been investigated ... DGD° values in the presence of these osmolytes are given in Table 1. How-ever, DGD° values of RNase-A in the presence of alanine, serine, lysine, b-alanine, taurine and dimethyl-glycine have ... havetherefore measured the thermodynamic parameters of RNase-A in the presence of these amino acids andamino acid derivatives, and values of DGD°, measured in triplicate, are given in Table...
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Báo cáo khoa học: Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel ppt

Báo cáo khoa học: Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel ppt

... analysis of initial rate data in the absence of inhibitors, we used the specific equation in Scheme 1. The effect of two ligands on the activity of the wild-type DmAChE was evaluated by the equation in ... 2B). In the case of the Glu mutation, the b value is linked to the k2value and thus both cannotbe estimated independently. However, if b is set to 1(i.e. the symmetry of the pS curve supporting ... substrateentrance. Thus, in the wild-type, the channel is so narrow that the ‘backdoor’ is used by at most 5% of the traffic, with the majority of traffic pass-ing through the main entrance. In mutants Trp83Ala...
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Báo cáo khóa học: Biochemical and molecular characterization of a laccase from the edible straw mushroom, Volvariella volvacea docx

Báo cáo khóa học: Biochemical and molecular characterization of a laccase from the edible straw mushroom, Volvariella volvacea docx

... conditions were: 1 cycle of 94 °Cfor3min,50 °Cfor30 s and 72 °C for 1 min; 30 cycles of 94 °C for 30 s, 54 °C for 30 s, and 72 °C for 1 min; then a final extension at 72 °C for 10 min before storage at ... single cysteine. This residue,which appears to have a role in determining the redoxpotential of the enzyme [33], can be methionine, leucine orphenylalanine. Therefore, lac1 with a leucine residue ... clones. The cDNA of lac1 contained an ORF of 1557 bp encoding 519 amino acids. The amino acid sequencefrom Ala25 to Asp41 corresponded to the N-terminalsequence of the purified protein. The first...
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Báo cáo khoa học:

Báo cáo khoa học: "COMMON TOPICS AND COHERENT SITUATIONS: INTERPRETING ELLIPSIS IN THE CONTEXT OF DISCOURSE INFERENCE" ppt

... with in the treatment of VP-eUipsis, perhaps at the cost of some degree of the- oretical inelegance. However, this aspect was crucial for handling the gapping data, since the infelicity of gapping ... Reference In this section we characterize the forms being ad- dressed in terms of two features: (1) whether the form leaves behind an empty constituent in the syntax, and (2) whether the form is ... anaphoric in the semantics. In subsequent sections, we show how the distinct mecha- nisms for recovering these types of missing information interact with two types of discourse inference to...
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Báo cáo khoa học: Distinguishing between different pathways of bilayer disruption by the related antimicrobial peptides cecropin B, B1 and B3 pptx

Báo cáo khoa học: Distinguishing between different pathways of bilayer disruption by the related antimicrobial peptides cecropin B, B1 and B3 pptx

... lMconcentration of the indicated peptide by application to the side of the vesicle-containing drop and was followed microscopically for the periodindicated. For CB, A–D were obtained at time (min) 0, ... was added before removal of the chloroform in anargon stream. Instead of our previous use of phosphatidyl-choline/PA (7 : 3) [27,33–42], PtdEtn used in these experi-ments is for the comparison ... using the manufacturer’s software and protocols. A diagram of the construction of the biosensor surface is shown in Fig. 1.Binding of peptides to the immobilized liposomes causes anincrease in...
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Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot

Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot

... accompanied by an increase in the rate of synthesis of Ino, without any need to modify the kineticparameters or activities of the enzymes involved in the pathway from ATP to Ino.Being aware of the simplifications ... concentration in a metabolic path-way as a function of the kinetic constants of the enzymesinvolved in that pathway [3]. Application of this methodpointed to the inhibition of the rate of synthesis of ... on the rate of synthesis of inosine. Application of the theoretical modelwas performed with the MATHEMATICA-3.0program, as described in the text and in [3].Simulation was made considering the...
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Báo cáo khoa học:

Báo cáo khoa học: "ON FORMALISMS AND ANALYSIS, GENERATION AND SYNTHESIS IN MACHINE TRANSLATION" pptx

... linguistic formalisms like those of the Government and Binding theory and the Lexical Functional Grammar theory. Our interest lies mainly in their role in the domain in terms of the ease in ... input to synthesis, may contain a mixture of the information. Some of this information are pertinent, namely the information associated to the level of transfer (in this case the semantic ... analysis), the synthesis phase has to be split into two subphases: the first phase has the role of transforming the input into a structure conforming to the one specified by the formalism...
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