Báo cáo khoa học: "Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series" pptx

... treatment of HIV, antiretroviral therapy(ART). There are currently ten PIs available; in chrono-logical order of FDA approval, saquinavir, ritonavir,indinavir, nelfinavir, lopinavir, atazanavir, ... Euhus DA, Place RJ, Huber PJ, Simmang CL:Outcome of HIV- infected patients with invasive squamous-cellcarcinoma of the anal canal in the era of highly active antiretroviraltherapy. Diseases of ... as: See et al.: Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series. Radiation Oncology 2011 6:25.See et al. Radiation Oncology...

Báo cáo khoa học: Crystal structure of the parasite inhibitor chagasin in complex with papain allows identiﬁcation of structural requirements for broad reactivity and speciﬁcity determinants for target proteases pptx

... Zoom -in view of the interactions of papain with loop L6 of chagasin and loop L2 of cysta-tin B. (C) Zoom -in view of the interactions of papain with loop L4 of chagasin and the N-terminal segment ... side-chain carbonyl Od1atom of N64e forms a water-mediated contact with the main-chain N atom of G68, and the main-chainnitrogen of G66 of chagasin forms a water-mediated A BCDFig. 2. Interactions ... Interactions of chagasin and cystatin B with papain. Color coding: chagasin (green)–papain (pink); cystatin B (brown)–papain (gray). (A) Stereoview of aligned molecules created by superposition of the Ca...

Báo cáo khoa học: Identiﬁcation of three proteins that associate in vitro with the Leishmania (Leishmania) amazonensis G-rich telomeric strand pdf

... annotatedas Rpa1, lacked the N-terminal domain (data not shown)that in other eukaryotes is involved only in Rpa–proteininteractions and has no function in binding DNA [ 45]. In addition, at ... 5¢-GTTAGGGTTAGGGTTAGG-3¢Tel6-Rev 5¢-CCTAACCCTAACCCTAAC-3¢Tel6RNA 5¢-GUUAGGGUUAGGGUUAGG-3¢Tet-tel 5¢-GTTGGGGTTGGGGTTGG-3¢T3 5¢-AATTAACCCTCACTAAAGGG-3¢T7 5¢-GTAATACGACTCACTATAGGG-3¢TS 5¢-AATCCGTCGAGCAGAGTT-3¢OvhF ... 5¢-CTGGCCGTCGTTTTACTTAGGGTTAGGGTTAGG-3¢OvhR 5¢-GTAAAACGACGGCCAG-3¢CSB1 5¢-GTACAGTGTACAGTGTACAGT-3¢5¢ biotinTel6 5¢ biotin-GTAATACGACTCGTTAGGGTTAGGGTTAGG-3¢3052 M. F. Ferna´ndez et al.(Eur....

Báo cáo khoa học: Crystal structures of bovine odorant-binding protein in complex with odorant molecules doc

... bOBP and pOBP) w ere incubatedwithafixedamountofAMA(3lM) and increasingconcentrations of odorants (0.39–50 lM). The chasing of AMA bound to OBP was followed a s a decay of t heemission of ... ProduzioniAnimali, Biotecnologie Veterinarie, Qualitaè Sicurezza degli Alimenti, Universita`di Parma, Parma, ItalyThe structure of bovine odorant-binding protein (bOBP)revealedastrikingfeatureofadimerformedbydomainswapping2[Tegoni, ... although bindingwas further localized in several t issues besides nasal mucosa.Another class of lipocalins – tear lipocalin-1 – was shownto bind with high affinity to a new class of receptor...

Báo cáo khoa học: Bilayer localization of membrane-active peptides studied in biomimetic vesicles by visible and ﬂuorescence spectroscopies pptx

... of melittin and KAL, butdoes not seem to a ect the strong interfacial binding of magainin. For example, at peptide concentrations of 2 lM,melittin induced a CR of % 20% in Ole2PtdSer/PamOle-PtdCho/PDA ... titaniumparticles.Ultracentrifugation binding assayAn ultracentrifugation binding assay was carried out forevaluating peptide afﬁnities to the vesicles (partition coef-ﬁcients [29,40]), in order to obtain an accurate ... Melittin also a induced slower relaxation (1.8 ns,Table 1), albeit to a lesser extent compared with magainin.KAL, on the other hand, gave an SR of 1.2 ns (Table 1)which is the smallest increase...

Báo cáo khoa học: "Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back" pot

... the clinical analysis of the dataset. CH and AvD performed the histopathological and molecular analysis. SC, JD, CH and AA analyszed the prognostic relevance of the molecular data. SC and CH ... such as cisplatinum might inactivate or attenuate MGMT-status thus influencing the clinical outcome when combined with alkylating chemotherapies. An important differential explanation is the variation ... in 66 patients, patients were treated with 3D-conformal radiation therapy based on CT- and MRI-based treatment planning. The median age of the patients included was 56 years at primary diagnosis...

báo cáo khoa học: "Increasing delivery of an outdoor journey intervention to people with stroke: A feasibility study involving five community rehabilitation teams" pps

... collaboration between physiotherapistsand occupational therapists, and involvement of t herapyassistants. Role sharing and expansion are examples of organisational interventions [35]. A more in- depthexamination ... followingtask-specific training [ 6]. One of these trials reportedincreased walking capacity following four weeks of treadmill training and overground walking practice in community-dwelling stroke ... South Wales,Australia. Quality and Safety in Health Care 2008, 17:329-333.28. National Stroke Foundation: National Stroke Audit Clinical Report: Acuteservices. Melbourne, Australia: National Stroke...

Báo cáo khoa học: Acute activation of Erk1/Erk2 and protein kinase B/akt proceed by independent pathways in multiple cell types ppt

... phosphati-dylinositol 3-kinase in the activation of glycogensynthase and mitogen-activated protein kinase by insulin in rat adipocytes: comparison of insulin and proteinkinase C modulators. ... a variety of conclusions. In ourlaboratory, we are interested in the relationshipbetween activation of two major signaling pathways:one initiated by p21ras proteins leading to activation of ... clear that activation of PLCc and PKC arealso intimately involved in the pathway leading to Erkactivation in B cells [36].Effects of PtdIns3K inhibitors in HEK293 cellsWe also wanted to examine...

Báo cáo khoa học: " Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dosevolume effects of pelvic radiotherapy" potx

... (Merck&Co.,Inc.,WhitehouseStation,NJ,USA),ahistonedeacetylase inhibitor, in combination with pelvic pallia-tive radiotherapy for advanced gastrointestinal carci-noma [5], and have experienced methodologicallimitations in determining maximum-tolerated ... typically in normal tissues with a hierarchical proliferative structure, such as the muco-sal lining of the gastrointestinal tract [2]. When combin-ing radiation with targeted therapeutics that ... NCT00455351FindingsContext With current advances in molecular radiobiology, strate-gies for improving efficacy of clinical radiotherapy areincreasingly focused on investigating targeted com-pounds as...

Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc

... Kmvalues increase from G1P overPhyK to AppA by a factor of  2200. The confor-mational changes of AppA upon substrate bindingfacilitate a faster turnover of phytate and are in line with a higher ... the nativedata with a resolution of 1.68 A ˚. Iterative cycles of modelbuilding and reﬁnement with arp ⁄ warp, refmac and oresulted in a ﬁnal model containing 796 of 836 amino acids,804 water ... glucose-1-phosphatase and human prostatic-acid phosphatase. The polypeptidechain is organized into an a and an a ⁄ b domain, and the active site islocated in a positively charged cleft between the domains....

Xem thêm