Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot

... 5:108http://www.ro-journal.com/content/5/1/108Page 9 of 12RESEA R C H Open Access The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiationJustine Rudner1, ... this article as: Rudner et al.: The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation. Radiation Oncology ... the levels of Mcl-1 in LNCaP cells. Thus, in LNCaP cells the down-regulation of the two anti -apoptotic Bcl-2 proteins may contribute to the antineoplastic effects of ErPC3 and radiotherapy.In...

Báo cáo khoa học: Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1 pot

... [28];labelling of the isoform containing this mutation was there-fore assigned the value of 100% after 300 min. Both the cysteine-less and G324C isoforms were incubated with10 lm probe for 300 min and ... to the other isoforms. The extent of labelling for each single-cyste-ine mutant was therefore determined by comparison withG324C. In order to calculate the speciﬁcity of labelling foreach single-cysteine ... transitions during the catalyticcycle. The previous section outlined the overall topog-raphy of TM12, by examining the accessibility of introduced cysteines to maleimide-containing probes. The next...

Báo cáo khoa học: "A Corpus for Modeling Morpho-Syntactic Agreement in Arabic: Gender, Number and Rationality" docx

... number and ratio-nality for nominals in our corpus. In terms of gen-der, the M value seems to be twice as common asF both in form and function. In 91.4% of all nomi-nals, function and form ... Nizar Habash, and Owen Rambow. 2011.Improving Arabic Dependency Parsing with Form-based and Functional Morphological Features. In Pro-ceedings of the 49th Annual Meeting of the Associ-ation ... August.362P , or U. And rationality can be R, I, B,9N orU. The annotators were given word clusters each of which consisting of a lemma and all of its sim-pliﬁed in ected forms appearing in the PATB....

báo cáo khoa học: "Chemoradiotherapy followed by surgery versus surgery alone in esophageal cancer patients: is it time for additional evidence?" doc

... chemoradiotherapy in technically operable IIa-IIIesophageal carcinoma is still unresolved.FindingsWe have read with interest the report from Hurmuzlu and coll [1] on the outcome of induction therapy ... treatment. In this scenario of substantial absence of a large base of methodologically correct evidence and agreed guidelineswe consider the results from [1] of significant clinicalvalue and concur in ... suchtrials the role of IT in the treatment of OC can becleared. More convincing arguments, in fact, need to sup-port any proposed change in clinical behaviour.Author details1Division of General...

Báo cáo Y học: Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells pot

... (j)arethemeanvaluesoffour replicates, and in the Northern analysis (h)themeanvaluesoftwo replicates. (B) The time sensitivity of GPR30 mRNA expressioncorrelated with the beginning of progestin-induced ... GPR30, the expression of which correlated withgrowth inhibition. The potential importance of the G-proteins in progestin-mediated signaling is also highligh-ted by a study showing that half of the ... unless otherwise indicated. Cells grown withoutMPA were used as a control. (A) The increase in GPR30 mRNAexpression and progestin-induced growth inhibition were dose-dependent. The values in the...

Báo cáo khoa học: Exogenous oxidative stress induces Ca2+ release in the yeast Saccharomyces cerevisiae potx

... solution of 1 lgÆlL)1 in meth-anol) was added to the cell suspension, and the cells wereincubated for 2 h at 28 °C in the dark. Aliquots containingapproximately 107 cells were harvested, and ... by the luminescence spectrum of the aequorin-expressing cells (Fig. 6A). This observation suggested that, as in the response to H2O2, cells utilize Ca2+-mediated signalingto initiate the ... by the uni-versal Ca2+sensor protein calmodulin, which can bind and activate calcineurin; this inhibits, at the post-tran-scriptional level, the function of Vcx1p [11,15,16] and induces the...

Tài liệu Báo cáo khoa học: Hepatic stimulator substance mitigates hepatic cell injury through suppression of the mitochondrial permeability transition pdf

... wasobserved in the HSS-expressing cells treated with CCCP as compared with the vector-transfected cells and cells expressing mutant HSS. Furthermore,silencing of HSS expression using small interfering ... wild-type cells (Fig. 1A). Protein expression of HSS in the three cell lines (untransfected cells, vector-transfected cells, and HSS-expressing cells) was detected using westernblot. As shown in Fig. ... leakage were signiﬁcantly inhibited in the HSS-expressing cells as compared with the untransfected cells, and, as a consequence, the cellular ATP content in the HSS-expressing cells wasrelatively...

Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx

... a solution of the protein. Typically an initial injection of 2 lL copperchelate solution was followed by a further 29 injections of 4 lL of Cu(II) into the protein in the sample cell stirredat ... human cystatins.Further support for the premise that the C-terminuscould be the copper binding domain comes from stud-ies of the P79S mutant, which differs from the copperbinding forms of steﬁn ... titrating steﬁn B protein withglycine alone was performed and no binding was observed. In our hands, as others [54], the most reproducible datawas obtained from injections of the metal into...

Tài liệu Báo cáo khoa học: "A Multimodal Interface for Access to Content in the Home" pdf

... understanding of system capa-bilities. Of the remaining 66% of inputs (2166) which were within the functionality of the system, 68% were in grammar. On the within functionality portion of the ... completing the same two sets of scenarios and then freely interacting with each system. For counterbalancing purposes, half of the subjects used the tablet and then the re-mote control and the other ... all of the search terms, except stop words, independent of the order (an AND query). If this fails, then it backs off further to an OR query of the search terms and uses an edit machine, using...

Báo cáo khoa học: Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model doc

... containmutated TP53). Further development of the assay toaddress these shortcomings offers the possibility of wider application of the assay to investigate some of the many outstanding uncertainties ... G, Invidia L, Vannini I, Rossi M, Marzi E et al.(2004) The different apoptotic potential of the p53codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death. Cell ... assess the effect of the mutagen on the pattern and spectrum of mutations. Inserts: morphology of HUFs at different stages of the HUF immortalization assay. Photomicrographs of cells growing in adherent...

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