Báo cáo khoa học: " Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma" docx

... of the sampleexhibiting staining); 2 (21-40% of the sample exhibitingstaining); 3 (41-60% of the sample exhibiting staining); 4(61-80% of the sample exhibiting staining), and 5 (81-100% of ... sample exhibiting staining); 3 (41-60% of the sample exhibiting staining); 4 (61-80% of the sample exhibiting staining), and 5 (81-100% of the specimen stained). The findings of the immunoreactivity ... Macchia V: Epidermal growth factor receptor in human brain tumors. J Endocrinol Invest 1992, 15(1):31-37.36. Johnson MD, Horiba M, Winnier AR, Artiaga CL: The epidermal growth factor receptor...

Báo cáo khoa học: Mutation of epidermal growth factor receptor is associated with MIG6 expression docx

... forindicating the intrinsic kinase activity of EGFR,regardless of tissue type.ResultsLigand-induced transcriptional signatures of EGFR-WT and L858R in the absence or presence of EGFR kinase ... FEBSIntroduction Epidermal growth factor receptor (EGFR) is a mem-brane tyrosine kinase that is involved in the regulation of a wide variety of biological processes [1]. Controlledactivation of EGFR is systemically ... state of EGFR, Src homology2 domain containing (SHC), mitogen-activated proteinkinase kinase (MEK) and extracellular signal-regulatedprotein kinase (ERK) in the absence or presence of EGF...

Báo cáo khoa học: Folding of epidermal growth factor-like repeats from human tenascin studied through a sequence frame-shift approach pdf

... folding in vivoThe folding in vivo of an extracellular protein containin gdisulfide-rich domains, the low-density lipoprotein recep-tor, has s hed new light on the folding process in the livin ... final native fold. In principle, twodifferent factors can determine the pairing of cysteines togive disulfide bonds in multidomain proteins: the topology of the disulfides within each repeat, and ... significance of the frame-shift a pproach in terms of t he kinetic a nd thermodynamic aspects that drivethe correct folding of EGF repeats within multidomainproteins, a nd in relation to the folding in...

Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot

... disintegrin and metalloprotein-ase) facilitated signaling by inducing the accumulation of TbRII in early endosomal vesicles and counteract-ing the internalization of TbRII into a caveolin1-posi-tive ... nucelo-porins. A lysine-rich nuclear localization signal (NLS)located in the N-terminal Mad homology 1 domain of all Smads binds to importin-b in the case of Smad3and importin-a in the case of Smad4, ... recyclingendosomes.RalA and RalBP1 appear to be involved in activinA receptor trafﬁcking and signaling (Fig. 1B). It hasbeen shown that activin receptor interacting protein 2(ARIP2) interacts...

Báo cáo khoa học: Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases docx

... matrixproteins such as ﬁbronectin, laminin, and type IV col-lagen, which facilitate the cellular invasiveness at theinvasion front [37]. Insulin-like growth factor- bindingproteins are also ... 2008 FEBS 1007 factor- binding proteins would increase the pericellularconcentration of insulin-like growth factor, and thiscould eventually stimulate invasive growth of tumorcells [21,40]. ... a-chain of the two-chain active form of HGF ⁄ SF,was used [14]. For detection of HGFA protein, a mAb to human HGFA (A-1), which recognized the light chain of the two-chain active form of HGFA...

Báo cáo khoa học: Transport of L-arginine and nitric oxide formation in human platelets pdf

... byL-leucine in thepresence, but not in the absence of Na+.The small inhibition of L-arginine in ux byL-leucine in the absence of Na+could be due probably to the presence of the system ... consisted of a rapid ﬁltration of platelets.The present report demonstrates that two Na+-inde-pendent main systems are involved in L-arginine transport in human platelets. The properties of one of ... for5–7% of the total arginine in ux. Thus its contribution toarginine in ux seems to be minor.To clarify the actual contributions of system y+and y+Lto the overall rate of L-arginine transport...

Báo cáo khoa học: "Transactivation of peroxisome proliferator-activated receptor alpha by green tea extracts" docx

... cells/well in 100µl of actinomycin Dcontaining the medium in 96-well plates. After 3 hours, thecells were incubated in the presence of GTE for 24 hrs.10µl of a MTT (5 mg/ml in PBS) were ... tea polyphenols includetheir antioxidant activity [17], modulation of carcinogen-metabolizing enzymes [9], trapping of ultimate carcinogens[16,18], inhibitory effect in respect of the nitrosationreaction ... administration of tea extract has beendemonstrated to inhibit the development of experimentalskin tumor of rodents [7], the growth of implanted tumorcells [13], and invasion and metastasis of...

Báo cáo khoa học: Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor doc

... androstadienolproduction from preg increases with increasing amounts of cyt b5 in presence of endogenous levels of P450red. In presence of these low levels of P450red, cyt b5shows aslight ... of P450c17 in the formation of this metabolite.Formation of androstadienol by human and porcineP450c17, with and without cytb5Using porcine and human P450c17 expressed in HEK-293 cells in culture, ... androstadienol, a precursor in the biosynthesis of Fig. 5. In uence of increasing concentrations of cyt b5on the relativeformation of androstadienol and DHEA by human P450c17. HEK-293cells...

Báo cáo khoa học: Assessment of telomere length and factors that contribute to its stability potx

... telomere bindingprotein, is present in more than 100 copies per chromosomeand is associated with the entire length of the telomere.Inhibition of TRF2 binding or blocking of the binding siteshas ... monitor prolifer-ation in a minor subset of cells and follow the acquisition of different markers in internal proteins linked to cell divisions. In the future, combination of this dye with Q-FISHFCMmayﬁnd ... well as recombination mechanisms and telomerase,all appear to be integral to maintaining the structuraland functional integrity of chromosomes. Assessment of these telomeric factors could provide...

Báo cáo khoa học: "Assessment of Replication and Virulence of Attenuated Pseudorabies Virus in Swine" pdf

... cDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, University of Iowa, Ames, Iowa USA,dDepartment of Avian Medicine, College of Veterinary Medicine, ... available for swine displaying clinical signs of infection with PRV. Currently, healthy animals are routinelyimmunized with inactivated (killed) or modified live virus(including those that are ... changes in the number and pattern of DNA fragments of virusesreisolated from tissues in comparison to PRV in theinoculum (i.e., PRV MS+1), strongly indicating that all theviral genomes were retained...

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