Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
Báo cáo y học: "Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases" pdf
... immune-modulatory potential. Five statins arecurrently available within the UK: pravastatin, simvastatin,fluvastatin, atorvastatin and rosuvastatin; in addition,lovastatin is available in other countries. ... derivatives, whereasfluvastatin, atorvastatin and rosuvastatin are entirelysynthetic [1]. Lovastatin and simvastatin are of the lactoneReviewDo the pleiotropic effects of statins in the vasculature predict ... colleaguesdemonstrated that simvastatin had a comparable anti-inflammatory effect to that of indomethacin in the carrageenan-induced foot pad oedema inflammatorymodel [43]. A large dose of simvastatin (100...
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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
... 6Research article Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation ... the assays and wrote the manuscript.AK (Allard Kaptein) helped in conceiving the study and helpedto draft the manuscript. AK (Annemieke Kavelaars) and CHwere involved in drafting and revising ... understanding of the role played byCyp7b in the arthritic process. The inhibitory effect of PSI on the TNF-α-induced upregulation of Cyp7b activity is also in accordance with a role for NF-κB in regulating...
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Báo cáo y học: "Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo" doc
... incubated byan alkaline phosphatase conjugated rabbit anti-rat immu-noglobulin (Dako) and the reaction was visualized using a ratalkaline phosphatase–antialkaline phosphatase complex(Dako), ... USA).Statistical analysisData are expressed as mean ± standard error of the mean. Expression of ERK, p38MAPKα and JNK in the different ther-apy groups and cell types was compared by means of Kruskal–Wallis ... and ERK in the synovial membrane, indicating that the intracellular effects of TNF can be inhibited. This suggeststhat anti-TNF therapy reduces key signalling pathways in the synovial membrane,...
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Báo cáo y học: "Tumour necrosis factor blockade and the risk of osteoporosis: back to the future " ppt
... to assess efficacy. Application of such auto-mated radiogrammetry to the existing clinical trial data (suchas these hand X-rays) offers an opportunity to examine the effects of TNF blockade ... months,Kalla and colleagues [12] reported significant effects onmetacarpal cortical width with sulphasalazine, antimalarials and injectable gold. Of interest, the manual technique of metacarpal morphometry ... that the availability of automated radiogrammetry means that the effect of TNF blockers on BMD could be easily assessed.Modern clinical trials with TNF blockers in RA have includedhand X-rays...
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Báo cáo y học: "The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis" potx
... produced athigh levels by macrophages localized in the lining layer and at the pannus lesion, induce the synthesis of numerous inflamma-tory mediators and matrix-degrading enzymes via the activa-tion ... infiltration of inflammatory cells, primarily lym-phocytes, and macrophages and proliferation of synovialfibroblasts, together with increased vascularity. Macrophagesplay a critical role in the ... concentrations were measured by cytometric beads array (using anticytokine monoclonal antibody [mAb]-coated beads and phycoerythrin-conjugated anticytokine mAbs). Values are the mean ± standard...
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Báo cáo y học: "Gene expression induced by interleukin-17 in fibroblast-like synoviocytes of patients with rheumatoid arthritis: upregulation of hyaluronan-binding protein TSG-6" doc
... inhibitor inter-α-inhibitor, and therebyincreases its anti-plasmin activity. This suggests a role for TSG-6 in the regulation of the plasmin/plasminogen acti-vator system and therefore the control of ... transcription system. The recombinant RNAwas quantified by the measurement of A 260 and used as a standard (after cDNA synthesis) in the quantitativeRT–PCR reaction.Quantitative PCR analysis For quantification, ... nylon membrane. After hybridization and washing, the array membrane was exposed to a phosphorimaging screen. Data analysis was performedwith AtlasImage Software 1.0. Expression values of tran-scripts...
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Báo cáo y học: "Giantin is the major Golgi autoantigen in human anti-Golgi complex sera" pptx
... putative AGA sera and normal control sera wereobtained from the laboratory serum bank and AdvancedDiagnostics Laboratory at the University of Calgary,Canada. Some AGA sera were also provided by Drs ... of the five antigens, five had antigiantin and antigolgin-245, two had antigiantin and antigolgin-160, two had antigiantin and anti-GM130, two had anti-giantin and antigolgin-97, two had antigolgin-245 ... golgin-160, golgin-95/GM130, and golgin-97) and provide data from epitopemapping on the most common Golgi autoantigen, namely giantin. A total of 80 human sera containing AGAs, as defined by indirectimmunofluorescence...
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Báo cáo y học: "Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production" ppt
... cells and human fibroblasts, as well as by gel zymography and an invasionassay. Significantly elevated release and activation of MMP-9 and/ or MMP-2 were seen in the co-culture of human monocytes/THP-1 ... participated in the design of the study and drafted the man-uscript. JD carried out the flow cytometry assay and the chem-otaxis assay, performed the statistical analysis and helped todraft the manuscript, ... macrophages may act as an amplifier of the pathoge-netic cascade in RA via an increase in MMP production byinteracting macrophages and fibroblasts.Bukrinsky and colleagues have reported that CD147...
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Báo cáo y học: "Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthriti" pptx
... patients in the late stages of OA, an increase in staining intensity was found in the pericel-lular space (Figure 4b). In healthy cartilage, COMP stainingwas also found in the territorial and ... joints. One sample, with a macroscopically normal appearance, was taken from the lat-eral aspect of a condyle. The other one was taken from the area adjacent to the main defect at a maximum of ... 5b,c). In contrast, in tissue samples from the area adja-cent to the main defect of OA cartilage of late stages of the disease, strong staining for COMP mRNA was detected in the cytoplasm of type...
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Báo cáo y học: "Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study" pot
... analysis and interpretation of data, statistical analysis, and manuscriptpreparation. NA participated in acquisition of data, analysis and interpretation of data, statistical analysis, and manuscriptpreparation. ... during OA by inducing the synthesis of major catabolic and inflammatory mediators via the p38 and p42/44 signalling pathways. Furthermore, PAR-2 upregulationby proinflammatory cytokines would amplify ... manuscriptpreparation. JMP and JPP participated in study design, analy-sis and interpretation of data, and manuscript preparation. NDparticipated in study design and in analysis and interpretation of data....
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