... U.S. The hepatitis C virus is an RNA virus that belongs to the family flaviviridae.[7] HCV replicates in the cytoplasm of hepatocytes, but is not directly cytopathic. Persistent infection ... understanding of the natural history of hepatitis C is essential to effectively manage, treat, and counsel individuals with HCV infection. Key words: Natural history, acute, chronic, hepatitis ... identify the patients at risk for HCV-related complications, and offer treatments to prevent further morbidity and mortality. 2. Routes of Transmission The transmission of HCV is primarily through...