Báo cáo y học: " Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis" pptx
Báo cáo y học: " Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis" pptx
... RT-PCR of the enzymes involved in the synthesis of these mediators (cyclooxygenase-2 (COX-2) and inducibleFigure 1Cytokine circulating levels in mice at the end of treatment in the collagen-induced ... transcriptionallyFigure 4 Effect of vasoactive intestinal peptide (VIP) on NFκB binding and IκB degradation in synovial cells from mice with collagen-induced arthritis (CIA )Effect of vasoactive intestinal peptide ... RANK in the joints of CIA mice to the levels detected in non-arthritic control mice.This effect may be due to the inhibition of RANK synthesis or,alternatively, to the inhibition of monocyte recruitment;...
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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt
... at the final stage of starch synthesis in the absence of concomitant amylopectin synthesis (reviewed in [41]). In vitrosynthesis of amyloseBecause in Chlamydomonas amylose synthesis remainsactive ... rates of amylose synthesis and we can onlystate that the latter certainly does not exceed the rate of amylopectin synthesis. The increase in crystallinity wit-nessed during these first 12 h is in ... pre-existing amorphous amylopectin into the formation of B-type crystals. Another mechanism would consist of crystallization of newly synthesized molecules into B-typematerial. This could involve only...
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Báo cáo Y học: Guanosine diphosphate-4-keto-6-deoxy-D-mannose reductase in the pathway for the synthesis of GDP-6-deoxy-D-talose in Actinobacillus actinomycetemcomitans potx
... ultrasonication. The cell extract was obtained bycentrifugation at 20 000 g for 30 min at 4 °C. Binding of the fusion proteins to chitin beads via the intein/chitin binding domain, cleavage of the fusion ... content of 48.0% [43]. The GC content of the region essential for the biosynthesis of SPA in the otherserotype strains (b–e) of A. actinomycetemcomitans is alsolower than the average GC content ... when about 50% of the GDP-a-D-mannose was used up. Addition of the proteinwas not effective in advancing the reaction. Conversely, in the Ôone-potÕ assay almost complete conversionTable 1. NMR...
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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... tolerance in the murine CIA model. We examined the change in the expression of IDO in CD11c+ DCs of Peyer's patches after repeated oraladministration of CII and subsequent induction of CIA. In freshly ... regula-tory effects on T cells that are mediated by tryptophan deple-tion and by the production of metabolic byproductscollectively known as kynurenines [16,21,22].Demonstrating the concomitant induction ... and erythema from the ankle to the tarsal bone, 3 = moderate edema and erythema from the ankle to the tarsal bone, and 4 = edema and erythema from the ankle to the entireleg. The sum of the values...
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Báo cáo y học: "Rho kinase inhibitors Y27632 and H1152 augment neurite extension in the presence of cultured Schwann cells" pdf
... The neurons plated onto coverslips not contain-ing SC invariably had some contaminating SC. In thiscase, only the neurites of neurons not in contact with SCwere included in the analysis. Two ... retraction of growth cones by increasing the net phos-phorylation of the myosin regulatory light chain. It alsoactivates Rho kinase (ROCK) which directly phosphor-ylates the regulatory light chain ... to in vivo peripheral nerveregeneration in the presence of Rho and Rho kinase inhi-bition remain undescribed.Conclusion In conclusion, we propose that inhibition of the RhoApathway in the...
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Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt
... concentration of Tb3+and protein was graduallyadded to the initial mixture. The fluorescence intensity wasnormalized by subtracting the contribution of the baselineslope using logarithmic fitting. The ... and the accompa-nying conformational change in the canonical EF-handare probably relayed to the SAM domain via the paired ‘hidden’ EF-hand, resulting in the oligomeriza-tion of STIM1 on store ... precipita-tion. For the Ca2+competition studies, the solution contain-ing 30 lm of Tb3+and 1.5 lm of protein was set as the starting point. The stock solution of 10–100 mm CaCl2with the same concentration...
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Báo cáo Y học: Dietary bisphenol A prevents ovarian degeneration and bone loss in female mice lacking the aromatase gene (Cyp19 ) pptx
... effects of xenoestrogens in the ovaries of ArKOmice in vivo.Estrogen plays an important role not only in the reproductive system but also in the regulation of bone metabolism to maintain bone ... exhibit marked bone loss due to increased bone resorption, and that the treatment with E2 restored the bone mass in ArKO mice [7]. To examine the effects of BPA on bone mass in ArKO mice, the femur ... the wild-type mice. In contrast, the BPA-containing diets did not cause any alterations of the uterine weight in the wild-type mice. Histological examina-tions showed that the uteri of ArKO mice...
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Báo cáo y học: "Subcutaneous Immunoglobulin-G Replacement Therapy with Preparations Currently Available in the United States for Intravenous or Intramuscular Use: Reasons and Regimens" docx
... of sitesand duration of each infusion. With the exception of the two infants, the other patients selected com-binations of these variables with which they werequite happy and on which they ... increase in local effects with continued infu-sions; they all became accustomed to and/or expe-rienced amelioration of any local redness or irri-tation at the sites of infusions as they continuedwith ... groundsduring IV therapy. A higher proportion of the patients listed in Table 4 were adults who may havebeen put on higher monthly doses because of chronic sinopulmonary infections.No patient had any...
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Báo cáo y học: "Improved cartilage integration and interfacial strength after enzymatic treatment in a cartilage transplantation model" potx
... area of fibrous ingrowth (circled). (b) Collagen type II, showing medium intensity staining (in red) in the entire matrix of the interfacial area. (c) Collagen type III; staining (in red) only ... mice. (a) Enzyme treated and (b) untreated control section. Note the clear differ-ence in thionin staining of the interfacial tissue between the enzyme-treated and control section. Interfaces ... evaluation.Evaluation of integrationCryosections were fixed in acetone and stained with0.04% thionin in 0.01 M sodium acetate for 5 min. For eachsample we assessed the percentage of total interfacelength...
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Báo cáo y học: "Challenges to conservation: land use change and local participation in the Al Reem Biosphere Reserve, West Qatar" pps
... participated in other aspects of the localeconomy; some of those living near to the Gulf coastworked in the pearling industry in the summer months,moving on with their herds for the rest of the year.Nomadism ... providing theirfamilies’ needs.14They do so seasonally, milking largely during the winter months , for although a camel will lactate for oneyear, they say that they milk for only some of this ... are part of ecosystems and they have to be considered alongwith other animals that inhabit any region in thinkingabout conservation, their activities inevitably intervening in nature’s arrangements...
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