Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc

Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc

Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc

... 2 Research article The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4 + CD25 + T cells Oliver Frey 1 , Peter ... With this in mind, it could be interesting to investigate whether the accumu- lated T reg cells in patients with arthritis function properly...
Ngày tải lên : 09/08/2014, 06:22
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Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

... CAAAAGTCTTGGCGGACAAAATGAGGACTTGGTAC Reverse CATTTTGTCCGCCAAGACTTTTGAATACTT TCAAGTGC Q76G Forward CTTCCCGGAGGAAATGAGGACTTGGTACTTACTG Reverse CCTCATTTCCTCCGGGAAGACTTTTGAATA C N77G Forward CGGACAAGGTGAGGACTTGGTACTTACTGGATAC Reverse ... contains three domains resembling family 2 cystatins. Cystatins competitively inhibit the activity of papain- like cysteine proteases by binding to the active s...
Ngày tải lên : 17/03/2014, 10:20
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf

Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf

... volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site. To test the ... effect of the mutations on the specificity for phenylacetylated substrates, the steady-state kinetic param- eters for the hydrolysis of the chromogenic substrate NIPAB and the...
Ngày tải lên : 17/03/2014, 23:20
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Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc

Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc

... finding that both MtaA mutants still bind coenzyme M and exhibit some activity although in both mutants the coordination of zinc differs from the situation in the wild-type enzyme. Apparently, other ... apparent absence of any sulfur in the first coordination sphere of Zn in the Cys239 fi Ala mutant suggests that Cys316 is not a direct Zn ligand in MtaA. It would be interesting...
Ngày tải lên : 17/03/2014, 23:20
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

... [12,13] suggest that correct orientation of the penicillin substrate with respect to the putative high-energy ferryl intermediate is important for optimum coupling between 2-oxoglutarate and penicillin ... substrate, and may be a consequence of the higher K m value for this substrate [1,22]. The third type of mutant, represented by arginines 306 and 307, are located in the C-ter...
Ngày tải lên : 18/03/2014, 01:20
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Báo cáo y học: "The role of Probiotics in allergic diseases" pptx

Báo cáo y học: "The role of Probiotics in allergic diseases" pptx

... as the timing of the introduction of the probiotic, Taylor et al administered the probiotic supplement postnatally, while other studies administered probiotics before and after birth. Prenatal supplementation ... in allergic disorders The interest in probiotic therapeutic potential in allergic disorders stemmed from the fact that they have been shown to reduce inflammatory cytok...
Ngày tải lên : 08/08/2014, 21:20
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Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc

Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc

... chal- lenging. The recruitment of sufficient numbers of patients to achieve statistical power, the development of reliable methods to measure the bone repair endpoint, and the randomization of patients ... the doses of indomethacin and celecoxib used in the rats were roughly equivalent to those used in patients, the dose of rofecoxib was nearly eight times that used to man...
Ngày tải lên : 09/08/2014, 01:21
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Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt

Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt

... of α-subunits, and two transactivating domains, namely the amino-terminal transactivating domain and the carboxyl- terminal transactivating domain (C-TAD). The C-TAD has been shown to interact with co-activators ... proteins, and the intracellular domain of the Notch receptor (involved in the maintenance of cells in an undifferentiated state), both of which notably contain...
Ngày tải lên : 09/08/2014, 01:22
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Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx

Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx

... of TNF-α and IL-1 are other currently used strategies. Both cytokines are potent osteoclastogenic factors, produced in inflammatory arthritis. Interestingly, clinical trials have shown that the ... 242 Osteoprotegerin as inhibitor of osteoclastogenesis Osteoprotegerin (OPG) has emerged as one of the most attractive tools to inhibit osteoclast formation during the past years. The in...
Ngày tải lên : 09/08/2014, 01:23
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Báo cáo y học: "The role of statins as potential targets for bone formation" pptx

Báo cáo y học: "The role of statins as potential targets for bone formation" pptx

... apposition rate in the tibiae of rats treated with cerivastatin at 0.1 mg/kg/day. Statins, there- fore, have the potential to stimulate bone formation both in vitro and in vivo in rats. Cerivastatin ... local production of the osteogenic protein BMP-2. Interestingly, pravastatin was unable to stimulate the BMP-2 promoter activity and it did not stimulate new bone formation in...
Ngày tải lên : 09/08/2014, 03:24
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