... association of heavy and light chain variable domainsin antibodies: implications for antigen specificityAnna Chailyan1,*, Paolo Marcatili1,* and Anna Tramontano1,21 Department of Physics, Sapienza ... Delagrave S, Catalan J, Sweet C, Drabik G, Henry A, Rees A, Monath TP & Guirakhoo F (1999) Effects of humanization by variable domain resurfacing on theantiviral activity of a single-chain ... comparable with the wild-type antibody, whereas the j-graft variant,although extraordinarily stable in vitro, had a five order of magnitude decreased antigen affinity, presumably,Table 2. Average...