... the combination of SE genecarriage and anti-CCP antibodies or an RF of any isotype, in comparison with individuals not having any of the factorsor having any one of them separately. In particular, ... Nishioka Y, Sekine A, Iida A, Takahashi A,Tsunoda T, Nakamura Y, Yamamoto K: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deimi-nase 4, are associated with rheumatoid ... understanding of theevents triggering the disease would be achieved, therebycreating the possibility of developing and testing preventivemeasures and of instituting therapy at earlier stages of dis-ease...