... [12].
Joint tissue engineering: clinical applications
The first entry for the key word ‘tissue engineering , also
termed ‘regenerative medicine’, in the National Center for
Biotechnology Information ... [55].
Cell sources for tissue engineering in
rheumatic diseases
Today, autologous chondrocytes represent the only cell type
routinely used for joint cartilage repair. In t...
... Two
clinical trials exploring the use of gene therapy in OA are
under way and another is in the pipeline. If successful, they
could lead to wide human and veterinary application and pave
the way ... as the Moloney murine
leukemia virus, were the first to be used in clinical trials and
dominated applications in human gene therapy for some
years, they are less popular now. Pse...
... treatment in the inflammatory rheumatic diseases
nowadays has become reaching and sustaining remission.
Clinical remission, meaning absence of clinically visible
disease manifestations, including the ... Heijde D, Bellamy N, Calin A, Dougados M, Khan MA, van
der Linden S: Assessments in Ankylosing Spondylitis Working
Group. Preliminary core sets for endpoints in ankylosing
spondyl...
... bipolar disorder in the
general population are likely receiving even less medical
care. The significance of this finding is that the psychiatrist
may be the only physician caring for these patients ... portacaval shunting, thereby decreasing first pass
metabolism; decrease in quantities and affinity of plasma
proteins, thereby increasing free-drug levels; increase in
volume of d...
... continuously being identified,
and these polymorphisms may play a pivotal role in
sporadic carcinogenesis. A growing body of literature,
including observations of inter-individual differences
in ... also involved non-enzymatically in the subsequent
5' incision. It is further involved in the stabilization of
a pre-incision complex on the damaged DNA.
The ERCC5/XPG gen...
... proposed to be the start of the protein
coding domain. Sequence analysis of the 3¢ end cDNA
revealed that there is a polyadenylation signal upstream of
the poly(A).
Analysis of the primary structure ... T. & Hoshi, M. (1992) The primary structure of the alpha
subunit of a starfish guanosine-nucleotide-binding regulatory
protein involved in 1-methyladenine-induced oocyte mat...
... mucous-secreting
glands; the effectiveness of the mucociliary system is
reduced, resulting in symptoms of nasal stuffiness. In
addition, a decrease in nasal blood flow leads to atrophy
and drying of the ... attention is paid in
the general medical literature. In the most recently pub-
lished highly regarded geriatric text, rhinitis is not
included in the index whereas...
... patients using the RPAS and the
AIMS, the second using the PANSS and the EPSE and the
third using the BARS. Information from the patient's his-
tory, concerning social-demographic and clinical ... psychopathol-
ogy symptoms, estimated by both the PANSS and the
BPRS.
We did not find any studies exploring the the relationship
between physical anhedonia and motor side...
... joints, and it results in the accumu-
lation of leukocytes within the synovial tissue (ST) and
synovial fluid (SF). The inflammatory infiltrate consists pre-
dominantly of B lymphocytes, T lymphocytes ... are another cell type expressing CXCR5
in the synovium. There have been several reports of
endothelial cells in the RA synovium expressing chemokine
receptors, including CXCR...
... early
bacterial infection in the joint. Somatic mutations in
mitochondrial peptides displayed by MHCs may be recognized
as non-self, furthering the destructive immune infiltration of the
RA joint. ... may also play a causative role in RA.
Competing interests
The author(s) declare that they have no competing interests.
Authors' contributions
TD participated in the design...