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Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt

Báo cáo y học:

Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt

... evidence for hypoxia in inflammatory and destructive joint disease, and discusses theinterplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... formyeloid cell-mediated inflammation and bactericidal capacity of phagocytes, suggesting crosstalk between angiogenesis and inflammation.Review Hypoxia The role of hypoxia and HIF-dependent signalling ... contains an evolutionarily conserved LxxLAPconsensus motif for hydroxylation by PHD, thus linking twomajor human signalling systems, namely NF-κB and HIF.Mimicking hypoxia by treatment of cells...
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Báo cáo y học:

Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" pps

... molecular basis of hypoxia tolerance, not only in muscle but also in numerous otherdiseases (including cancer and RA) and in settings whereinduction of hypoxia tolerance might be of therapeutic ... contains an evolutionarily conserved LxxLAPconsensus motif for hydroxylation by PHD, thus linking twomajor human signalling systems, namely NF-κB and HIF.Mimicking hypoxia by treatment of cells ... consider the potential role of hypoxia in the pathogenesis of RA.Why is hypoxia a feature of rheumatoid arthritis?Tissue hypoxia results from an inadequate supply of oxygen,with resultant effects...
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Báo cáo y học: "The role of F1 ATP synthase beta subunit in WSSV infection in the shrimp, Litopenaeus vannamei" potx

... non-coding sequence of 20 bp and 3 conserved domains including F1ATP synthase betasubunit nucleotide-binding domain, ATP synthase alpha/beta chain N terminal domain, ATP synthase alpha/betachain ... administration of the hostVP28-Binding protein PmRab7 ( or an antibody againstit ) could reduce and delay mortality upon subsequentFigure 3 Compete ELISA binding assay. Graph showing decreasing ... BP53 was one of the bindingproteins against WSSV.Innoculum preincubation with rBP53 delayed mortalityfrom WSSV challengeTo identify whether BP53 play rol es in involvi ng WSSVinfection, the...
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Báo cáo y học: "The role of pleiotrophin and β-catenin in fetal lung development" doc

... W, Yamin M, Noda M, et al.: Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein ... pathway is possibly medi-ated by the c-Src, which binds to the intracellular domain of syndecan-3 and subsequently alters the activity of cort-actin [68].ALK is a receptor tyrosine kinase highly ... Perez-Pinera P, Deuel TF: Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin....
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Báo cáo y học: "The role of ATP and adenosine in the control of hepatic blood flow in the rabbit liver in vivo" pps

... derivative of 8-phe-nyltheophylline (8-PT, 8-(p-sulphophenyl)-theophylline(8-SPT) (Research Biochemicals Inc.), to the arterial and venous perfusate. Single HA doses of acetylcholine (ACh,10-7 ... inhibi-tion of HA responses by 8-SPT between intra-arterial and intra-portal injection of ATP despite a longer lag-timebetween injection and response following intra-portalinjection of ATP. This ... changes in hepatic arterial flow (∆ HAF) in vivoFigure 3The effect of intra-portal injection of (a) ATP and (b) adenosine on changes in hepatic arterial flow (∆ HAF) in vivo. Both agents increased...
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Báo cáo y học: "The incidence of multidrug and full class resistance in HIV-1 infected patients is decreasing over time (2001–2006) in Portugal" potx

... interpretation of the genotypic resistance information. In particular, thedecline in resistance can be partially explained by the factthat in the early years of 2000, treatment initiation in patients ... treatedpopulation in Portugal, since every patient on treatment isnormally genotypically tested when failing. Our analysiswas performed using the number of patients with a geno-type in the denominator ... before July 2001, wereexcluded from the analysis of MDR, or FCR respectively.While this may not have eliminated the bias entirely, thecontinuing decreasing trends of MDR (and FCR) even in the...
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Báo cáo y học:

Báo cáo y học: "Skewed distribution of proinflammatory CD4+CD28null T cells in rheumatoid arthritis" docx

... important role in the pathogenesis of rheumatoid arthritis (RA) (reviewed in [1]). In the synovialjoint, infiltrating T cells are predominantly of the CD4+ pheno-type and are often found in the ... clinical evaluations of patients and manuscriptpreparation. VM and CT were the principle investigators and participated equally in the planning and coordination of thestudy, interpretation of ... Helsinki Dec-laration by the Ethics Committee of the Karolinska UniversityHospital, and all patients and healthy subjects gave informedconsent.Arthroscopy and synovial biopsiesKnee joint synovial...
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Báo cáo y học: "Antiviral activity of Engystol® and Gripp-Heel®: an in-vitro assessment" pptx

... penicillin and 0.1 mg/mlstreptomycin). Cells were incubated in serum-free MEMcontaining 1 μg/ml trypsine, 2 mM L-glutamine, 100 U/mlpenicillin and 0.1 mg/ml streptomycin.Determination of virus ... Friedrich-LöfflerInstitute (FLI) Tübingen a nd the Department of MedicalVirology and Epidemiology of Virus Diseases of theHygiene Institute at University of Tübingen, respectively.For IFN assaysHeLa ... signalling, modulating thedevelopment of innate and adaptive immune systems[17,18]. Apparently, the induction of IFN type I mole-cules results from activation of distinct interacting path-ways dependent...
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Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

... second binding loops of cystatin B and family 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction.To elucidate the role of the second binding loop of ... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute  45% of the totalunitary free energy of binding of cystatin A to ... cathepsin B,demonstrating a major role of the second binding loop of cystatin A in the inhibition of this enzyme. Pro74 may bedirectly involved in the interaction with cathepsin B byproviding hydrophobic...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf

Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf

... and volume of the acyl binding pocket and thereby alter the binding mode and affinity of theenzyme for PAA and derivatives thereof, while maintainingthe hydrophobicity of the binding site.To ... (kcat/Km)forp-hydroxyphenylgly-cine methyl ester and phenylglycine methyl ester that weresimilar to the wild-type values, whereas the specificity con-stants for p-hydroxyphenylglycine amide and phenylglycineamide ... methyl ester or the amide asacyl donor.It appeared that 6-APA and 7-ADCA were able toefficiently deacylate the phenylglycyl- and p-hydroxyphe-nylglycyl-enzyme of bF24A, as indicated by, respectively,...
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