Báo cáo y học: "An analysis of correlations among four outcome scales employed in clinical trials of patients with major depressive disorder" pdf
Báo cáo y học: "An analysis of correlations among four outcome scales employed in clinical trials of patients with major depressive disorder" pdf
... purposes)Annals of General PsychiatryOpen AccessPrimary researchAn analysis of correlations among four outcome scales employed in clinical trials of patients with major depressive disorderQin Jiang* ... [4-6].The present analysis was undertaken in a large dataset of 22 double-blind, placebo-controlled, clinical studies of venlafaxine in patients with MDD to identify and assess correlations among these ... Mont-gomery-sberg Depression Rating Scale, the HamiltonDepression Rating Scale and the Clinical Global ImpressionsRating Scale in antidepressant clinical trials: a replication analysis. Int Clin Psychopharmacol...
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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... activity in the smallintestine and the epididymis of mice. Arch Biochem Biophys1980, 203:343-351.33. Malina HZ, Martin XD: Indoleamine 2,3-dioxygenase: antioxidantenzyme in the human eye. Graefes ... Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J Clin Invest 2004, 114:280-290.19. Munn DH, Sharma MD, Baban B, Harding HP, Zhang Y, Ron ... cells of tolerized miceOral tolerance induction in indoleamine 2,3-dioxygenase-expressing CD11c+ dendritic cells of tolerized mice. The induction of oral tolerance increases the proportion of indoleamine...
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Báo cáo y học: "Rho kinase inhibitors Y27632 and H1152 augment neurite extension in the presence of cultured Schwann cells" pdf
... vari-ety of systems. This pyridine derivative is the oldest syn-thesised and reported specific inhibitor of Rho-kinasefamily enzymes. Y2 7632 inhibits ROCK activity by com-petitive binding with ... cones by increasing the net phos-phorylation of the myosin regulatory light chain. It alsoactivates Rho kinase (ROCK) which directly phosphor-ylates the regulatory light chain of the major cytoplasmicmyosin, ... coverslips not contain-ing SC invariably had some contaminating SC. In thiscase, only the neurites of neurons not in contact with SCwere included in the analysis. Two coverslips were used in each experiment...
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Báo cáo hóa học: " Some nonlinear delay integral inequalities on time scales arising in the theory of dynamics equations" ppt
... 2011:29http://www.journalofinequalitiesandapplications.com/content/2011/1/29Page 5 of 14RESEA R C H Open AccessSome nonlinear delay integral inequalities ontime scales arising in the theory of dynamicsequationsQinghua ... 26D10.Keywords: delay integral inequality, time scales, dynamic equation, bound1 Introduction In the 1980s, Hilger initiated the concept of time scales [1], which is used as a theorycapable ... nonlinear delay integral inequalities on time scales arising in the theory of dynamics equations. Journal of Inequalities and Applications 2011 2011:29.Feng et al. Journal of Inequalities and...
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Báo cáo y học: "Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapy" ppt
... vimentin is present in synovialmembranes and is released in increased amounts in responseto growth factors and proinflammatory cytokines, suggestinginvolvement in the pathophysiology of RA [24]. The ... largely subjec-tive [4].Anti-filaggrin antibodies recognize citrulline residues formedby post-transcriptional modification of arginine by peptidy-larginine deiminase [5]. Enzyme immunoassays ... purposes)early RA in our study was too small for a statistical evaluation of these data.Changes in anti-mutated citrullinated vimentin titres during infliximab therapy Of the 80 patients with anti-CCP...
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Báo cáo y học: " Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience" pdf
... contri-buted greatly to our understanding of disc remodeling in degenerative IVD, notably the role of pro-inflammatorycytokines. They compare the expression of IL-1β and TNFαas well as their main functional ... with an increase in IL-1βcompared to TNFα and a low level of cells positive for TNFreceptor type I [1]. In degenerated human IVDs, although theprotein production of the two cytokines was increasedcompared ... challenge in osteoarthritisand results from animal models suggest that IL-1ra may havebeneficial effects. The clinical benefit of a local injection of IL-1ra in knee osteoarthritis may be limited by...
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Báo cáo y học: " Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab the" pdf
... vimentin is present in synovialmembranes and is released in increased amounts in responseto growth factors and proinflammatory cytokines, suggestinginvolvement in the pathophysiology of RA [24]. The ... largely subjec-tive [4].Anti-filaggrin antibodies recognize citrulline residues formedby post-transcriptional modification of arginine by peptidy-larginine deiminase [5]. Enzyme immunoassays ... purposes)early RA in our study was too small for a statistical evaluation of these data.Changes in anti-mutated citrullinated vimentin titres during infliximab therapy Of the 80 patients with anti-CCP...
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Tài liệu Báo cáo Y học: Functional analysis of DM64, an antimyotoxic protein with immunoglobulin-like structure from Didelphis marsupialis serum pdf
... residues phenylalanine and tyrosine typical of the Ig-fold are bold in each domain.Fig. 5. Inhibition of in vivo myotoxicity of myotoxins I or II by DM64.Groups of four mice were injected intramuscularly ... DM64 binds to the myotoxins through a myotoxic/cytolytic site distinct from the catalytic site, as alreadydescribed for the inhibition of myotoxicity by heparin [44].At least in the case of B. ... Neutralizing interaction between heparinsand myotoxin II, a lysine 49 phospholipase A2from Bothropsasper venom. Identification of a heparin-binding and cytolytictoxin region by the use of synthetic...
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Báo cáo Y học: Kinetic analysis of hydroxylation of saturated fatty acids by recombinant P450foxy produced by an Escherichia coli expression system docx
... Protein conxentration was determined using theBio-Rad protein assay reagent (Bio-Rad Laboratories Inc.,CA, USA).Data analysis Steady state kinetic analyses for P450foxy were examined with varying ... x-3 hydroxy fatty acids,respectively.2080 T. Kitazume et al. (Eur. J. Biochem. 269) Ó FEBS 2002Kinetic analysis of hydroxylation of saturated fatty acidsby recombinant P450foxy produced by anEscherichia ... from Tyr to Phe. Why substrate inhibition isobserved only with P450foxy may be explained by thesesubstitutions. The first interaction of P450BM3 with fattyacids may occur between the carboxylate...
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Báo cáo y học: "Functional analysis of an arthritogenic synovial fibroblast" docx
... histological analysis of injected joints revealed ahigh incidence of disease transfer (Table 1), characterizedby variable degrees of synovitis, soft-tissue inflammation,synovial hyperplasia, ... thepresence of the transgene could be detected in only theinjected knee. Careful analysis of the fibroblast-containingorgans did not show any evidence of tissue pathology; thisfinding suggests ... inflammatory processes, as well as a complexinterplay between different cell types.Cytokines play an essential role in the regulation of theimmune system and they have been implicated in inflam-matory...
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