... forclinical use, there was also a marked reduction insymptoms and histopathology if the antagonist was givenonly after the disease had already developed. The protective effect on cartilage and bone ... of one ligand or receptormay be compensated for by other members of the superfamily. In addition, some ligands may be agonists atone receptor and antagonists at others. Another issue isthat ... and other chronic inflammatory disorders.Keywords: chemokines, rheumatoid arthritis, synovial tissue9721. Ogata H, Takeya M, Yoshimura T, Takagi K, Takahashi K: The role of monocyte chemoattractant...