... likely to participate inmediating protein–protein interactions than in nucleicacid binding.DiscussionSensitive sequence profile–profile comparison methodscombined with comparative modeling revealed ... modelingCorrespondenceCˇ. Venclovas, Institute of Biotechnology,Vilnius University, Graicˇiuno 8, LT-02241Vilnius, LithuaniaFax: +3 70 5 260 2116Tel: +3 70 5 269 1881E-mail: venclovas@ibt.ltWebsite: ... kaustophilusreplicative polymerase [8].Gram-negative and Gram-positive bacteria separatedover a billion years ago [9], providing ample time fordivergent evolution of DnaE and PolC. However,despite...