... probably induced by streng-thening of the interaction between the structural TnC-binding site and the C-domain of TnC accompanyingCa2+binding to site IV of TnC. In vertebrate tropo-nin, the ... regulatory TnC-binding site,from actin, resulting in the release of the inhibitionand muscle contraction [17]. The structural TnC-bind-ing site interacts with the C-domain of TnC in both the relaxed ... of Ca2+switching involving the alternative binding of the C-terminal region of TnI to actin or TnC in a Ca2+-dependent manner [17,19]. On the other hand, the inhibitory effect of ATnI232)292was...