... upstreamregion and entire intron, an upstream enhancer module at)2.5 kb, and 5¢, middle and 3¢ modules of the first intronwere tested. The main effects of the respective modules and their combinatorial interactions ... bothcell types. In C2/7, but not in FTO-2B cells, the upstreamenhancer and the 5¢-intron modules lost their stimulatoryactivity in the context of the upstream region and the entireintron, respectively. ... (muscle). The application of the ANOVAtechnique allowed us to segregate the main(intrinsic) activities of the respective elements from the effects of their interactions. Using this approach, the upstream...