Báo cáo khoa học: " Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial pithelial cells" pot
Báo cáo khoa học: " Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial pithelial cells" pot
... (2004),/5(4), 369–378 Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial epithelial cellsSeo-Hyun ... cap-independent protein translation was responsible for early apoptosis. To understand the relative roles of cap-dependentand -independent protein translations in NNK-induced apoptosis in human ... showed thatNNK induced apoptosis in concentration- and time-dependent manners. NNK-induced apoptosis occurred initially through cap-independent protein translation, which during later stage...
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Tài liệu Báo cáo khoa học: Prion protein library of recombinant constructs for structural biology docx
... are distributed free of charge to not -for- profitinstitutions.AbbreviationshPrP, human prion protein; mPrP, mouse prion protein; PrP, prion protein; PrPC, cellular form of prion protein. FEBS ... prion protein (PrP) in its ‘cellularform’ (PrPC) in healthy organisms is intimately relatedto susceptibility to transmissible spongiform encephal-opathies, such as scrapie in sheep, bovine ... mouse prion protein constructs and variantsthereof, is presented. This includes information on the biochemistry of therecombinant proteins, in particular on successful and unsuccessful expres-sion...
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Báo cáo khoa học: b-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins pot
... recog-nizing the N-terminus [W1NT (A)] and C-terminus [W1CT (C)] of APLP1. Western blotting for GAPDH was included to check for equal protein loading (E). Lysates of a cell line overexpressing human ... removed, and the remainingbrain was cut in half along the midline, snap frozen in liquid nitrogen, and stored at )80 °C until analysis. Levelsof BACE1 protein in all of the brain tissues analyzed ... and C-terminalfragments of APP [C8 (E)]. Western blotting for GAPDH was included to check for equal protein loading (F). Lysates of a cell lineoverexpressing human WT APP695(+) wereincluded...
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Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
... domain binding motif in their C-termini.PDZ domains have been established as sites for protein protein inter-action and play a central role in organizing diverse cell signaling assem-blies. In ... domains are modular protein protein interac-tion domains, which are amongst the most abundant protein interaction domains in organisms from bacteriato mammals, and have been implicated in various ... present in the PDZ binding motifs ofother membrane proteins [17]. We also found interac-tion of PDZ domains 1 + 2 with ORs showing noclassical PDZ binding motifs, indicating that theunderstanding...
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Tài liệu Báo cáo khoa học: Cell-free translation systems for protein engineering docx
... have resulted in their use for protein production in the laboratory. These systems have protein engineering appli-cations, such as the production of proteins containing unnatural aminoacids and ... we generate integral membrane proteinswithin liposomes, and is there any way to integrateproteins into the lipid bilayer in the proper conforma-tion? Recent progress in answering these questionsarose ... fluorescent protein; GFP, green fluorescent protein; PDI, protein disulfide isomerase; PURE, protein synthesis usingrecombinant elements; scFv, single-chain variable fragment of antibody; Sec, secretory;...
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Tài liệu Báo cáo khoa học: Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain doc
... detect Cyp4x1 in brain; quantitation of the Cyp4x1 protein in brain demonstrated 10 ngof Cyp4x1 protein mg)1microsomal protein, showing that Cyp4x1 is amajor brain P450. Immunohistochemical ... preincubatedwith purified recombinant Cyp4x1 protein, resulting in the ablation of detection of the 55-kDa protein in brain(Fig. 5C). This shows that the antisera specificallydetect the murine ... Cyp4x1Æmg)1microsomal protein (Fig. 5D). This suggests thatCyp4x1 is a major brain cytochrome P450 form [23].Cyp4x1 immunohistochemistry in brainThe primary antiserum was used to locate Cyp4x1 protein by...
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Báo cáo khoa học: The F13 residue is critical for interaction among the coat protein subunits of papaya mosaic virus doc
... 1479monomeric form of the protein [10]. This protein failedto assemble, form disks or interact with RNA in vitro[10]. On the basis of this result, we hypothesized thatthe N-terminus of the CP is involved ... well as for mapping domains of CPs involved in this process. Therecombinant NLPs, with an average length of 50 nm,represent 20–30% of the total purified proteins. Theremaining protein is essentially ... PapMV CP indicated that anessential domain for CP multimerization is located on26 amino acids of the N-terminus [9,10]. In this work,we investigated this region in detail, introducing dele-tions...
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Báo cáo khoa học: Signal peptide hydrophobicity is critical for early stages in protein export by Bacillus subtilis ppt
... chains to increase thelabelling efficiency. The nascent chain correspondingto the authentic preprotein comprised 101 aminoacids, while the nascent chain corresponding to theLeu and Ala preproteins ... chain;?, unknown cross-linking adducts;*, cross-linking adducts with E. coli L23;d, cross-linking adducts with E. coli Ffh;s, cross-linking adducts with B. subtilis Ffh;n, cross-linking ... Secretory protein targeting in Bacillus subtilisFEBS Journal 272 (2005) 4617–4630 ª 2005 FEBS 4621B. subtilis is not responsible for the lack of export ofAmyQ containing the Ala signal peptide.In...
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Báo cáo khoa học: Human delta-lactoferrin is a transcription factor that enhances Skp1 (S-phase kinase-associated protein) gene expression pdf
... permeabilized for 2 min in 0.15% TritonX-100 in NaCl ⁄ Pi, and washed again twice in NaCl ⁄ Pi.Glass slides were next placed in a solution containing 1%ethanolamine in NaCl ⁄ Pi for 20 min at ... an F-box protein, which acts as a recep-tor for target proteins. Skp1 is an adaptor between oneof the variable F-box proteins and Cullin. At the G1⁄ Stransition, the F-box protein is Skp2, ... Skp1 ⁄ Cullin-1 ⁄ F-box ubiquitin ligase (SCF)complex is singled out in this work, as its temporalcontrol of ubiquitin–proteasome-mediated protein deg-radation is critical for normal G1-...
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Tài liệu Báo cáo khoa học: Multisite protein phosphorylation – from molecular mechanisms to kinetic models pdf
... Kv2.1 potassiumchannel in mammalian neurons [11]), protein kinases(e.g. MAP kinases [12,13] and Src family kinases [14]),adaptor proteins (e.g. SH2-domain containing leuko-cyte protein of ... nucleotidephosphodiesterase 3B; RS, arginine-serine repeats; SH2 domain, Src homology 2 domain; SP, serine–proline repeat; SRPK, serine-arginine-rich protein kinase; SRR, serine-rich regions; TCR, T-cell ... 3193Concluding remarksNotwithstanding the interesting developments in recent years reviewed here, the kinetic analysis andaccompanying mathematical modelling of multisite protein phosphorylation is...
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