... presence of PA activity was also investi-gated using plasminogen–gelatin zymography. Gelatingels run without plasminogen were used as controlsagainst gels containing plasminogen and gelatin. Indeed,when ... acinarcells [4]. All these cells have granules which contain alarge variety of serglycin-binding molecules, includinghistamine, chymases, gelatinase, granzymes, plateletfactor 4, lactoferrin ... important for the genesis of gran-ules. Inactivation of the gene encoding histidinedecarboxylase, the enzyme converting histidine tohistamine, resulted in reduced storage of PG and pro-teases in...