... which was indeed predicted. The other maingroup, obtained 97% of the time in 20 740 exploredtrees, contained the DIDO PHD sequences clusteredwith the PHF and the CGBP proteins. As seen in the tree, ... distribution (Fig. 1), in which the SPP1 representatives are at the basal branch of CGBP and DIO. The GCBP proteins contain a PHD domain, fol-lowed by a DNA-binding domain (the zf-CXXC) and the newly described ... modifications of chromatin [9]. Little isknown, however, of the functional role of the remain-ing subclass members. In this study, the yeast protein SPP1 (alias cps40), amember of the COMPASS...