Chapter 083 Cancer of the Skin (Part 9) ppt
Chapter 083. Cancer of the Skin (Part 9) ppt
... Chapter 083. Cancer of the Skin (Part 9) Squamous Cell Carcinoma The natural history of SCC depends on both tumor and host characteristics. Tumors arising on actinically damaged skin ... decrease the rate of NMSC in xeroderma pigmentosum. Squamous Cell Carcinoma The therapy of cutaneous SCC should be based on an analysis of risk factors influencing the biologic behavior of the ... tumor. These include the size, location, and degree of histologic differentiation of the tumor as well as the age and physical condition of the patient. Surgical excision, MMS, and radiation therapy...
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Chapter 083. Cancer of the Skin (Part 1) ppt
... on the palms and soles. Lateral Chapter 083. Cancer of the Skin (Part 1) Harrison's Internal Medicine > Chapter 83. Cancer of the Skin Melanoma Pigmented lesions are among the ... Dark-skinned populations (such as those of India and Puerto Rico), blacks, and East Asians have rates 10–20 times lower than lighter-skinned whites. In keeping with the role of sun exposure, the ... exposure to sun than individuals of similar age who were either born in those countries or immigrated before age 10. The individuals most susceptible to development of melanoma are those with fair...
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Chapter 083. Cancer of the Skin (Part 2) ppsx
... Shades of brown mixed with bluish red (violaceous), bluish black, reddish brown, and often whitish pink, and the border of lesion is at least in part aDuring much of this time, the ... spreading melanoma is the most frequent variant observed in the white population. Melanomas arising in dysplastic nevi (see below) are usually of this type. The back is the most common site ... confined to the epidermis. Source: Adapted from AJ Sober, in Pathophysiology of Dermatologic Diseases, NA Soter, HP Baden (eds). New York, McGraw-Hill, 1984. A fifth type of melanoma, the desmoplastic...
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Chapter 083. Cancer of the Skin (Part 4) pot
... from RJ Friedman et al: CA—A Cancer J Clinicians 33(3):130, 1985. Chapter 083. Cancer of the Skin (Part 4) Management The entire cutaneous surface, including the scalp and mucous membranes, ... areas; the back is the most common site, but dysplastic nevi may also be seen on the scalp, breasts, and buttocks Generally on the sun-exposed surfaces of the skin above the waist; the scalp, ... nodes and palpation of the abdominal viscera are part of the staging examination for suspected melanoma. The patient should be advised to have other family members screened if either melanoma or...
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Chapter 083. Cancer of the Skin (Part 5) ppsx
... color from flesh to tan, to dark brown. Chapter 083. Cancer of the Skin (Part 5) A lifetime risk of melanoma development of 6% has been estimated. The risk is greatest before age 5 and next ... Early detection of melanoma is difficult in these lesions because of the deep dermal or subcutaneous origin of primary melanoma and because of the large and varied surface of the nevus. Prophylactic ... mm (the size of a pencil eraser). Of these criteria, the weakest is diameter >6 mm since a significant fraction of melanomas are now diagnosed with diameters <6 mm. In addition, the above...
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Chapter 083. Cancer of the Skin (Part 6) potx
... thick) reported that the narrower margin resulted in higher rates of local recurrence but no difference in rates of nodal or distant metastases, Chapter 083. Cancer of the Skin (Part 6) Biopsy ... excision of the lesion with a margin of normal skin is necessary to remove all malignant cells and minimize possible local recurrence. The appropriate width of the margin is a source of controversy. ... feasible (such as the face, hands, or feet), an incisional biopsy through the most nodular or darkest area of the lesion is acceptable; this should include the vertical growth phase of the primary...
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Chapter 083. Cancer of the Skin (Part 7) doc
... telangiectatic tumor border. Chapter 083. Cancer of the Skin (Part 7) Treatment of Metastatic Disease Melanoma can metastasize to any internal organ, the brain being a particularly common ... skin such as the head, neck, hands, and arms are other typical sites of involvement. C. Actinic keratoses consists of hyperkeratotic erythematous papules and patches on sun-exposed skin. They ... and the use of genetically altered tumor cells to elicit a T cell response. Alternative experimental approaches include efforts to expand tumor-specific T cells (either obtained from the tumor...
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Chapter 083. Cancer of the Skin (Part 10) pps
... Jr et al: The histogenesis and biologic behavior of primary human malignant melanoma of the skin. Cancer Res 29:705, 1969 [PMID: 5773814] Friedman RI et al (eds): Cancer of the Skin. Philadelphia, ... 258:3146, 1987 [PMID: 3312689] Chapter 083. Cancer of the Skin (Part 10) Other Nonmelanoma Cutaneous Malignancies Neoplasms of cutaneous adnexa and sarcomas of fibrous, mesenchymal, fatty, ... combination therapy for advanced squamous cell carcinoma of the skin. J Natl Cancer Inst 84:235, 1992 [PMID: 1734084] Marks R: An overview of skin cancers. Incidence and causation. Cancer 75(Suppl):607,...
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Chapter 029. Disorders of the Eye (Part 9) potx
... Ophthalmoscopy reveals zones of whitened, edematous retina following the distribution of branch retinal arterioles. Complete occlusion of the central retinal artery produces arrest of blood flow and a ... 29-6). Emboli are composed of either cholesterol (Hollenhorst plaque), calcium, or platelet-fibrin debris. The most common source is an atherosclerotic plaque in the carotid artery or aorta, ... term refers to a transient ischemic attack of the retina (Chap. 364). Because neural tissue has a high rate of metabolism, interruption of blood flow to the retina for more than a few seconds results...
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Chapter 085. Neoplasms of the Lung (Part 9) ppsx
... if the patient would otherwise be considered for curative treatment. In SCLC, CT scans are used in the planning of chest radiation treatment and in the assessment of the response to chemotherapy ... lymph node stations for lung cancer staging. (Used by permission from CF Mountain, C Dresler: Chest 111:1718, 1997.) Chapter 085. Neoplasms of the Lung (Part 9) Chest radiographs and ... nomenclature for referring to the location of lymph nodes involved with cancer has evolved (Fig. 85-1). Unless the CT-detected abnormalities are unequivocal, histology of suspicious extrathoracic...
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