... segment ofguinea pig MBP, Gln74-Lys75-Ser76-Gln77-Arg78-Ser7 9- Gln80-Asp81-Glu82-Asn83-Pro84-Val85 [MBP(74–85)].Arg78 is proximal to a triproline Pro99-Pro100-Pro101segment, which h as been ... imolecular complexMHC II antigen [MBP(74–85)].Materials and methodsSynthesis of peptide analogues of MBP(74–85)The linear MBP analo gues Gln-Lys-Ser-Gln-Arg-Ser-Gln-X-Glu-Asn-Pro-Val, wh ere X ¼ ... of the potent linear dodecapeptide epitope ofguinea pig MBP, Gln74-Lys75-Ser76-Gln77-Arg78-Ser7 9- Gln80-Asp81-Glu82-Asn83-Pro84-Val85 [MBP(74–85)],and its antagonist analogue Ala81MBP(74–85)....