THE MOLECULAR BASIS OF PLANT GENETIC DIVERSITY pdf
Báo cáo khoa học: The molecular basis of heme oxygenase deficiency in the pcd1 mutant of pea pot
... characterized the contribution of these assay components by omitting them individually.In the absence of ferredoxin the reaction ratedecreased to 46.5% of the complete reaction while the absence of ascorbate ... account for the failure of the PsHO1 probe to detect any HO2-likesequences in Southern blot experiments. Whatever the basis of the recovery of phytochrome responses inolder pcd1 plants, they still ... nucleotides of the exons, respectively. (C) Phylogenetic tree of plant HO-likesequences. The protein sequence for the mature region of PsHO1was aligned with mature sequences of previously identified plant HO...
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Molecular Basis of Pulmonary Disease Insights from Rare Lung Disorders pdf
... maintaining the same degree of efficacy with the f ewestnumber of subjects exposed to the more toxic therapy.There are a number of alternative study designs that can be considered in the context of rare ... measure the actual difference between treatment outcomes.There are many approaches to the design of a trial and many of them can achieve cer-tain economies in terms of the required number of participants ... approaches to the design of a trial and many of them can achieve certaineconomies in terms of the required number of participants that need to be enrolled.However, the options are not without their...
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Báo cáo khoa học: Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the crown domain potx
... confirmed by the kinetic analysis of a purified GPI-anchorless solubleversion of the mutant protein. The Kcat⁄ Kmvalue of the mutant TNSALP was less than one-tenth of the Kcat⁄ Kmvalue of the ... TNSALP (R433C). The rate of the intracellulartransport of the mutant protein was similar to that of the wild-type protein, as assessed by the acquisition of Endo H resistance. Besides, the mutant ... top of the gel. Molecular basis of perinatal form of hypophosphatasia N. Numa et al.2730 FEBS Journal 275 (2008) 2727–2737 ª 2008 The Authors Journal compilation ª 2008 FEBS Molecular basis of...
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Báo cáo khoa học: Transthyretin and familial amyloidotic polyneuropathy Recent progress in understanding the molecular mechanism of neurodegeneration pdf
... showing the location of amyloidogenic mutations and position of b-strands. (A) The struc-ture of the polypeptide backbone of the two chains (purple andblue) is shown along with the location of the ... within a tissue and that the distribu-tion of TTR deposition reflects the presence of theseendogenous factors. In the case of the Ab protein of Alzheimer’s disease, a number of proteins and factors(pathological ... [146], Hou et al. [141] foundthat the binding of TTR to the membrane and the extent of disruption of membrane fluidity correlatedwith the degree of toxicity. In another study, Houet al. [140] showed...
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Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc
... USA) and sequenced to verify the presence of the mutation and the absence of any other substitution intro-duced during the PCR. Mutated genes were further cloned in the pET28 expression vector ... saturatingconcentration of the co-substrate. When determining the Km3-phosphoglycerate of the wild-type and mutant enzymes, the concentration of GTP present in the assay was at least 10times their respective ... to that of Gly312 in the pig enzyme. On the other hand, the Leu residue present in the horseand yeast enzymes is conserved in the majority of PGK sequences reported to date; however, in the EhPGK,...
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Báo cáo khoa học: The lactate dehydrogenases encoded by the ldh and ldhB genes in Lactococcus lactis exhibit distinct regulation and catalytic properties ) comparative modeling to probe the molecular basis pdf
... lactate, the activity of LDHB was 86% of the value determined in the absence of lactate, and at300 mm lactate, the activity of LDHB was only 24% of the same control value.Characterization of glucose ... Examination of the model of the R state of LDH shows a much higher density of posi-tive charge in the region of contact between the mono-mers than in LDHB, particularly in the region of contact ... activator of LDHB with aKact of 2.0 ± 0.5 mm.Piwas nearly as effective asFru(1,6)P2for activation of LDHB, insofar as the maximal activity in the presence of Piwas 70–80% of the maximal...
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Báo cáo Y học: A polymer with a backbone of 3-deoxy-D-glycero -D-galacto -non-2ulopyranosonic acid, a teichuronic acid, and a b-glucosylated ribitol teichoic acid in the cell wall of plant pathogenic Streptomyces sp. VKM Ac-2124 pdf
... proves the position of the acetamido groups at C-2and C-3 of this sugar. The signal of the H-5 of this sugarappeared as a doublet, which suggests the absence of protons at H-6. In addition, the ... wereobserved in the region of resonances of the CH3CO– groups. The presence of 3-deoxynonulosonic acid with the b-configuration of the glycosidic bond followed from twodoublets of doublets at ... H-1(D)/C-8(C)at4.55/79.40 p.p.m. in the HMBC spectrum. The downfied shift of the C-4 resonance of the b-Kdn residue in the 13CNMRspectrum of this polymer equal to 2 p.p.m. as compared tothat of nonsubstituted...
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EVOLUTION OF THE MOLECULAR BIOLOGY OF BRAIN TUMORS AND THE THERAPEUTIC IMPLICATIONS pdf
... mortality of the patient. Moreover, the presence of the blood-brain barrier(BBB) limits the passage of a wide variety of anticancer agents. The high incidence of recur‐rence and poor prognosis of ... that genetic instability of high gradegliomas provides the way of angiogenesis independently of hypoxia (such as chronic HIFEvolution of the Molecular Biology of Brain Tumors and the Therapeutic ... 21:207–215Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications20cies. Elevated versican production occurs in either the tumor cells or the stromal cellssurrounding the tumor....
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