... initiallythought to be limited to the classical pathway, but recentreports have also indicated increased concentrations of the alternative activation factors Bb and Ba, and Factor H, a regulatory factor ... detected at 3 months of age, and increases withage; total A burden peaks at one year of age, although thepercentage of A that is fibrillar (thioflavin-S reactive)increases up to 2 years of age. ... of human aging and dementia.Neurobiol Aging 1996, 17:259-28.142. Kimura N, Tanemura K, Nakamura S, Takashima A, Ono F, SakakibaraI, Ishii Y, Kyuwa S, Yoshikawa Y: Age-related changes of Alzhe-imer's...