... both memory and naïve B cells, as demonstrated by upregulation of CD86, CD70, CD40, and MHC class I and II. CP-870,893-activated B cells induced T cellproliferation and T cell secretion of effector ... both memory and naïve B cellscan be activated by the drug CP-870,893, and this CP-870,893 effect can be increased by the addition of CpGODN 2006. Naïve B cells, as defined by lack of CD27expression, ... expres-sion. CD40-ligand (CD40L), also known as CD154, is thechief ligand for CD40 and is expressed primarily by acti-vated T cells and platelets [10,11]. The interaction of CD40 and CD40L represents...