... our knowledge, these associationsare novel, and might contribute t o the understanding of the involvement of the liver-spleen axis and FM in the pathogenesis of low IGF-I status in obesity.Previous ... the relevant role of SLD, and extends the investigation to other components of the IGF-I axis,such as IGFBP-1, an emerging marker of HS severity in clinical situations [20], as is the case of ... [29]. In any case , these points needto be addressed again in a larger populat ion-based sam-ple, using also MRI abdominal imaging, or by measure-ment of other cytokines (mainly IL-6) to further...