... Italy, Netherlands, Norway,Spain, Sweden and the UK) and in six countries around the world in TREAT RLS 2 (Australia, Canada, Germany,Norway, the UK and the USA). After a wash-out phase of generally ... be as clinicallyrelevant.Authors' contributionsLA, EM, JK, and RPA all participated in the design of the study. LA and RA wrote the analysis plan and supervised the analysis. All authors ... standard deviation of mean scores atbaseline. The ES has been recommended in the literatureas an appropriate benchmark for evaluating the magni-tude and meaning of change in health status measures[22].Cohen...