... binding of these cells by activated microglia, known to be present in increased numbers in the PD substantia nigra [3]. C3a, the other major C3 cleavage protein, is an anaphylatoxin,increasing ... staining,numbers of melanized neurons, and the duration of PD.Results: Lewy bodies in both PD and DLB specimens stained for iC3b and C9. Staining was alsoprominent on melanized neurons. The ... to be pro-inflammatory [27-29] because itattracts and activates eosinophils, basophils, and mastcells, few of these cells are present in the brain. C3a may, in fact, limit brain inflammation,...