... morn-ing [21-24], being consistent with the findings of this study. However, in the NDP group, the pattern of circadian rhythm in 5-FU pharmacokinetics was cer-tainly different from that in ... but when using NDP instead of CDDP, it is necessary to look for some marker capable of indicating clinical re-sponse. In conclusion, only a small number of patients were enrolled in this study, ... effects of replacing cisplatin (CDDP) with cis-diammineglycolatoplatinum (nedaplatin, NDP), a second-generation platinum complex, on the pharmacokinetics of 5-fluorouracil (5-FU) were investigated...