... cleavage of the c-phosphate does occur in the NBD with the mutation at the IC [36,38,39]. More-over, these and other studies suggest that the ICresidues are involved in the formation of the NBDdimer, ... transporters in the lipid bilayer and the changes associated with dimerization and opening of the NBDs [11–14]. In these 3D structures,it is thus possible to observe the position of eacha helix in the ... motifs, the signature or LSGGQ motif and the A-, D-, H- and Q-loops. These motifs are positionedaround the bound nucleotide and help to position and maintain it in the active site. In particular, the Walker...