... to the study design, acquisition of data, analysis and interpretation of data, and the writing of this manuscript. MAW participated in the analysis and interpretation of data and the writing of ... conception,design, and writing of this manuscript. IO conceived thisstudy, oversaw its design and coordination, supervised the analysis and interpretation of the data, and writing the manuscript. All ... IGFBP-3 and -4 expression and age, gender,tumor thickness, histopathologic subtype, and metastatictumor type were evaluated by the t -test (or Wilcoxon rank-sum test) , the analysis of variance (ANOVA)...