... 9:75http://www.translational-medicine.com/content/9/1/75Page 3 of 8REVIEW Open Access The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical settingAlessandra Maleddu1*, ... the extracellular side of the receptor, a trans-membrane portion and an intracellular part containingtwo tyrosine kinase domains: one with an adenosine tri-phosphate (ATP) binding region and ... 16:97-101.43. Wakai T, Kanda T, Hirota S, Ohashi A, Shirai Y, Hatakeyama K: Lateresistance to imatinib therapy in a metastatic gastrointestinal stromaltumour is associated with a second KIT mutation....