... RESEA R C H Open AccessSERCA2a gene transfer improves electrocardiographic performance in aged mdx miceJin-Hong Shin1, Brian Bostick1, Yongping Yue1, Roger Hajjar2and Dongsheng ... (reviewed in [1]). Dystrophin is a largesub-sarcolemmal protein that plays a critical role in maintaining sarcolemma integrity. In a dystrophin-defi-cient heart, myocardial contraction results in ... phin /ut ro-phin double knockout mice and dystrophin-deficientFigure 3 AAV-9 SERCA2a expre ssion improves the ECG profile in mdx mice. A, Representative single lead II tracin gs f rom BL10, mdx...