... -performed bioinformatic analysis, CW - performed flow cytometry analysis, SR - designed and interpreted MS data, SH - designed, collected and interpreted clinical data, ST- designed and interpreted experiment, ... admitted to Ramathibodi Hospital,Bangkok, Thailand and two normal donors. All patientswere children 3-12 years-old and had symptoms of severeanemia and hepatosplenomegaly. Hemoglobin analysis showed ... theintrinsic and the mitochondria dependent apoptoticpathway. The activation of v arious death stimuli triggersthe localization of pro-apoptotic proteins Bcl-2 and BH3family into mitochondria...