Báo cáo hóa học: "High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma A feasibility study" pptx
... article as: Guida et al.: High activity of sequential low dose
chemo-modulating Temozolomide in combination with Fotemustine in
metastatic melanoma. A feasibility study. Journal of Translational Medicine
2010 ... Open Access
High activity of sequential low dose
chemo-modulating Temozolomide in
combination with Fotemustine in metastatic...
... the bk
cat
values clearly approach a
nonzero limiting activity at low pH. Limiting activity is the
plateau value in a titration curve. All of the titrations extend
over a range of at least 3 pH ... essential features of the catalytic
site (i.e. a catalytic triad of Ser-His-Glu, an oxyanion hole, a
p-cation-binding site, and an acyl-binding pocket) are the
same in A...
... concentration of urea and detergents interfere
with any available protein assay system, we adapted a tur-
bidimetric assay especially for samples prepared for 2D
analysis[13]. In this assay, proteins are ... damage. Nature 1999, 401(6753):616-620.
25. Osada H, Tatematsu Y, Yatabe Y, Nakagawa T, Konishi H, Harano T,
Tezel E, Takada M, Takahashi T: Frequent and histological type-
specif...
... Moreover, at low concen-
tration, the staining curve increased faster than at higher
concentration, indicating a two-component binding
interaction. Indeed, using a root mean square minimiza-
tion analysis ... was analysed using modelling software
(SAAMII, v1.2, University of Washington).
Statistical analysis
Statistical analyses were carried out using the biostatistic
software GraphPa...
... multivariate analysis of different prognostic factors in 123 patients with hepatocellular
carcinoma (Cox Proportional Hazards Regression)
Univariate analysis Multivariate analysis
Variable All cases ... temperature, and stained
with DAB (3,3-diaminobenzidine). Finally, the sections
were counterstained with Mayer’ s hematoxylin, dehy-
drated, and mounted. A negative control was obt...
... quantity of laminin beta-2 chain
(LAMB2) precursor was significantly higher than other
laminins (Table 1; Figure 2). About the same quantity of
laminin alpha-5 chain (LAMA5) was expressed in ... Dolado I, Swat A, Nunez A, Cuadrado A, Nebreda AR,
Casal JI: Proteomic analysis of p38alpha mitogen-activated
protein kinase-regulated changes in membrane fractions of
RAS-transformed f...
... Assessment and Accreditation of
Laboratory Animal Care International) approval.
Treatments with cancer cells and ascorbic acid
Sarcoma 180 cells were cultivated in a CO
2
incubator for
five days, adding ... intraperitoneal adminis-
tration of a high dose concentration of ascorbic acid quan-
titatively up-regulated Raf kinase inhibitory protein
(RKIP) and annexin A5 expressio...
... urinary bladder: an update based on the
Ancona international consultation. Virchows Arch 2002, 440:3-11.
20. Althausen AF, Prout GR, Daly JJ: Non-invasive papillary carcinoma of the
bladder associated ... that even in patient s with papillary disease,
most invasive cancers develop from adjacent areas of
carcinoma in situ [3]. However, in order to modify t he
natural history of b...
... two
modes of administration at the individual item level and
overall scores indicate that telephone administration of
these instruments is a valid method of obtaining this
information from elderly patients ... taking part in a larger evaluation of a novel
home-based rehabilitation program following discharge
from hospital participated in this study. Any person over
the age...
... scores indicate that
fatigue has a greater impact on the individual. The MFIS
has been suggested as a useful measure of fatigue in MS
research and clinical practice [30].
Data analysis
Data was analysed ... and
collation, data analysis, writing and editing of the manu-
script. CM was involved in the conception and design of
the study, as well as data analysis and writing and edi...