... factors for exacerbations in both the health status and the physiological status, and theseresults are compatible with the close relationship between the severity of COPD and the high risk of ... manuscript.SS collected the data and prepared the initial manuscript.MT, TH, AI, HK and TO participated in data collection and the care for the participants. SS and TO performed the sta-tistical ... statistically and clinically significantdeclines in three domains of the CRQ (Fatigue, Emotion, and Mastery), and in all three components and the totalscores of the SGRQ (Figure 3 &4). These results...