... p53 and p105Rb, leading to transfor-mation and carcinogenesis [2], facilitate cell immortalisa-tion in primary human keratinocytes [3], increasegenomic instability [4], and maintain the transformedphenotype ... Department of Medical Pharmacology, Università di Milano, Milan, ItalyFull list of author information is available at the end of the articleRadaelli et al. Journal of Translational Medicine ... 347:1523-1527.23. Adams M, Borysiewicz L, Fiander A, Man S, Jasani B, Navabi H, Lipetz C, Evans AS, Mason M: Clinical studies of human papilloma vaccines in pre-invasive and invasive cancer. Vaccine 2001,...