... domainMMP-1, -3 , -8 , -1 0, -1 2, -1 3, -1 9, -2 0, -2 7Furin-activatedMMP-23MT1, -2 , -3 , -5 -MMPMT4, -6 -MMPZnNCZnNZnNZnNZnNZnNZnNCCNZnZnNCatalytic domainPropeptide domainHinge-regionHPX ... byfurin-like proteinases. The two gelatinases (MMP-2 and -9 ) contain three FnII-like repeats in their catalytic domain, N-terminal to the catalyticZinc-binding site. Four of the six MT-MMPs ... TIMP-2 in the MT1-MMP-induced activation of proMMP-2,but also enhanced the activation of proMMP-2 by allMT-MMPs. Claudin-1 binds to both MT1-MMP and proMMP-2, and this binding appears to involve...