... ª 2007 FEBSTo analyze the contribution of protein domains to the ER anchorage, the localization of the full-lengthenzyme was compared with those of five truncatedforms. The pattern of the full-length ... enzymes. The most significant difference between the amphi-oxus and the other retinal reductases was, nevertheless,their preference for the NADH cofactor. To ourknowledge, these are the first ... [29]. The overall analysis, examining the topology of the phylogenetic tree and the position of each gene inside the cluster, was informative regard-ing the orthology relationships of the distinct...