... and TKRPR were employed as pivotalendogenous factors in evolutionary lineages distinctfrom oct-TKs.Two possible scenarios concerning evolutionary aspects of oct-TKs and oct-TKRPs can be assumed:(a) ... Abbott, NJ.22 Bockaert J & Pin JP (1999) Molecular tinkering of Gprotein-coupled receptors: an evolutionary success.EMBO J 18, 1723–1729.23 Donnelly D, Maudsley S, Gent JP, Moser RN, HurrellCR ... implica-tions. Biochem J 339(1), 55–61.24 Kanda A, Satake H, Kawada T & Minakata H (2005)Novel evolutionary lineages of the invertebrateoxytocin ⁄ vasopressin superfamily peptides and theirreceptors...