... (C-fibers, conduction ve-locity 0.2–2.0 m/s) and myelinated ax-ons (A!-fibers, 5–30 m/s). The free end-ings of A! fibers respond to intensepressure or heat, those of C-fibers re-spond to chemical ... A2 and formsthe substrate of cyclooxygenases and lipoxygenases.Synthesis of prostaglandins (PG),prostacyclin, and thromboxane pro-ceeds via intermediary cyclic endoper-oxides. In the case of ... reactive N-acetyl-p-benzoquinonimine, which is detoxi-fied by coupling to glutathione. After in-gestion of high doses (approx. 10 g), theglutathione reserves of the liver are de-pleted and the...