... levels of regula-
tion: the synthesis of the cyclins and their assembly into
cyclin/Cdk complexes [14], the phosphorylation of the
Cdks, and the inhibitory action of the Cdk inhibitors (CKIs)
in these ... Rat1 /ras cells at the G1 phase of the
cell cycle, following up-regulation of the cell cycle inhibitor
p27
Kip1
and down-regulation of the...
... in
nontransfected, Scramble- and ANT1 and
ANT2 siRNA-transfected cells. (D) Western
blot analysis of ANT protein in Scramble-
and ANT1 and ANT2 siRNA-transfected
cells; the 33 kDa band corresponds to ... ANT1 and ANT2 transcripts in
nontransfected ADF cells. (B) Number of
ANT1 transcripts in nontransfected, Scram-
ble- and ANT1 and ANT2 siRNA-transfected
cells. (...
... focusing, topic shifts, the use
of pronominal noun phrases to refer to antecedents in focus, and
the use of non-pronominal noun phrases to refer to antecedents not
in focus.
224
Gross and ...
independent converging analyses: a) the distribution of non-
pronominal and pronominal noun phrases b) the distribution of
antecedents of pronominal and non-pro...
... BVR-B
and BVR-A is likely to involve the B-face hydrogen
atom attached to C4 of the nicotinamide ring and the
two bridging pyrroles (rings B and C) with the linking
C10 methene bridge as the electrophilic ... inhibitors of BVR-A.
With this in mind, and in the absence of a crystal
structure of the ternary complex of BVR-A with pyri-
dine nucleotide and...
... coexpression of
angiotensin I and bradykinin B
2
receptors in HEK-293
cells increases the efficacy and potency of angiotensin
II, but it also reduces the ability of bradykinin to sti-
mulate inositol phosphate ... GPCR–b-arres-
tin interaction. (A) The sequential binding
of the ligands to each half of the receptor
dimer induces the recruitment of two
molecules...
... phenylanine at this
position in the 5HT2 subfamily of serotonin receptors
has been suggested to be involved in ligand binding
[87]. On the other hand, early experimental studies
pointed to the involvement ... algorithms
and the selection of the sequences in the alignment
determine the nature of the answers returned by the
application of the computationa...
... cargo binding sites, referred to as
the major and minor binding sites [1]. These sites are
located in the concave face of the protein near regions
of invariant Trp and Asn arrays. The major binding
site ... positioned at the end of the
binding pocket.
In total, the CLIC4 NLS main chain and side chains
make 174 atom -to- atom van der Waals’ contacts with
importi...
... hex-
amerins, crustacean hemocyanins, crustacean pseudohemocyanins, chelicerate hemocyanins, myriapod hemocyanins and one onychophoran
hemocyanin. The onychophoran hemocyanin (EpiHc1) was used to root ... Crustacean hemocyanins and pseudohemo-
cyanins form a third clade with 1.00 posterior proba-
bility and 100% bootstrap support. The monophyly
of crustacean and hexapod hemocy...
... increase the
activity of aB-crystallin against DTT-induced precipi-
tation of insulin at intermediate and high concentra-
tions, and it also increased the activity of aB-crystallin
in preventing the ... 20 min, and the
increase in light scattering due to precipitation of the
protein reached a maximum after 90 min (Fig. 3A).
All of the additives tested inc...
... 2008)
doi:10.1111/j.1742-4658.2008.06522.x
The folding of eukaryotic DNA into the 30 nm fibre comprises the first
level of transcriptionally dormant chromatin. Understanding its structure
and the processes of its folding and unfolding ... crosslinking of nucleosomes and digestion of the DNA to mononucleosome size of samples con-
sisting of a mixture of hepta-,...