Báo cáo khoa học: The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest pdf

Báo cáo khoa học: The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest pdf

Báo cáo khoa học: The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest pdf

... levels of regula- tion: the synthesis of the cyclins and their assembly into cyclin/Cdk complexes [14], the phosphorylation of the Cdks, and the inhibitory action of the Cdk inhibitors (CKIs) in these ... Rat1 /ras cells at the G1 phase of the cell cycle, following up-regulation of the cell cycle inhibitor p27 Kip1 and down-regulation of the...
Ngày tải lên : 31/03/2014, 01:20
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc

Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc

... in nontransfected, Scramble- and ANT1 and ANT2 siRNA-transfected cells. (D) Western blot analysis of ANT protein in Scramble- and ANT1 and ANT2 siRNA-transfected cells; the 33 kDa band corresponds to ... ANT1 and ANT2 transcripts in nontransfected ADF cells. (B) Number of ANT1 transcripts in nontransfected, Scram- ble- and ANT1 and ANT2 siRNA-transfected cells. (...
Ngày tải lên : 29/03/2014, 09:20
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Tài liệu Báo cáo khoa học: "The Structure of User-Adviser Dialogues: Is there Method in their Madness?" pdf

Tài liệu Báo cáo khoa học: "The Structure of User-Adviser Dialogues: Is there Method in their Madness?" pdf

... focusing, topic shifts, the use of pronominal noun phrases to refer to antecedents in focus, and the use of non-pronominal noun phrases to refer to antecedents not in focus. 224 Gross and ... independent converging analyses: a) the distribution of non- pronominal and pronominal noun phrases b) the distribution of antecedents of pronominal and non-pro...
Ngày tải lên : 21/02/2014, 20:20
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Báo cáo khoa học: The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXa reductase and human biliverdin-IXb reductase potx

Báo cáo khoa học: The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXa reductase and human biliverdin-IXb reductase potx

... BVR-B and BVR-A is likely to involve the B-face hydrogen atom attached to C4 of the nicotinamide ring and the two bridging pyrroles (rings B and C) with the linking C10 methene bridge as the electrophilic ... inhibitors of BVR-A. With this in mind, and in the absence of a crystal structure of the ternary complex of BVR-A with pyri- dine nucleotide and...
Ngày tải lên : 16/03/2014, 02:20
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Báo cáo khoa học: The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology pptx

Báo cáo khoa học: The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology pptx

... coexpression of angiotensin I and bradykinin B 2 receptors in HEK-293 cells increases the efficacy and potency of angiotensin II, but it also reduces the ability of bradykinin to sti- mulate inositol phosphate ... GPCR–b-arres- tin interaction. (A) The sequential binding of the ligands to each half of the receptor dimer induces the recruitment of two molecules...
Ngày tải lên : 16/03/2014, 22:20
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Báo cáo khoa học: The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics doc

Báo cáo khoa học: The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics doc

... phenylanine at this position in the 5HT2 subfamily of serotonin receptors has been suggested to be involved in ligand binding [87]. On the other hand, early experimental studies pointed to the involvement ... algorithms and the selection of the sequences in the alignment determine the nature of the answers returned by the application of the computationa...
Ngày tải lên : 16/03/2014, 22:20
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Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

... cargo binding sites, referred to as the major and minor binding sites [1]. These sites are located in the concave face of the protein near regions of invariant Trp and Asn arrays. The major binding site ... positioned at the end of the binding pocket. In total, the CLIC4 NLS main chain and side chains make 174 atom -to- atom van der Waals’ contacts with importi...
Ngày tải lên : 14/02/2014, 19:20
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Tài liệu Báo cáo khoa học: The occurrence of hemocyanin in Hexapoda docx

Tài liệu Báo cáo khoa học: The occurrence of hemocyanin in Hexapoda docx

... hex- amerins, crustacean hemocyanins, crustacean pseudohemocyanins, chelicerate hemocyanins, myriapod hemocyanins and one onychophoran hemocyanin. The onychophoran hemocyanin (EpiHc1) was used to root ... Crustacean hemocyanins and pseudohemo- cyanins form a third clade with 1.00 posterior proba- bility and 100% bootstrap support. The monophyly of crustacean and hexapod hemocy...
Ngày tải lên : 18/02/2014, 08:20
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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

... increase the activity of aB-crystallin against DTT-induced precipi- tation of insulin at intermediate and high concentra- tions, and it also increased the activity of aB-crystallin in preventing the ... 20 min, and the increase in light scattering due to precipitation of the protein reached a maximum after 90 min (Fig. 3A). All of the additives tested inc...
Ngày tải lên : 18/02/2014, 16:20
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Tài liệu Báo cáo khoa học: The sequentiallity of nucleosomes in the 30 nm chromatin fibre pptx

Tài liệu Báo cáo khoa học: The sequentiallity of nucleosomes in the 30 nm chromatin fibre pptx

... 2008) doi:10.1111/j.1742-4658.2008.06522.x The folding of eukaryotic DNA into the 30 nm fibre comprises the first level of transcriptionally dormant chromatin. Understanding its structure and the processes of its folding and unfolding ... crosslinking of nucleosomes and digestion of the DNA to mononucleosome size of samples con- sisting of a mixture of hepta-,...
Ngày tải lên : 18/02/2014, 18:20
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