0
  1. Trang chủ >
  2. Luận Văn - Báo Cáo >
  3. Báo cáo khoa học >

Báo cáo khoa học: Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm pdf

Tài liệu Báo cáo khoa học: Identification of Ewing’s sarcoma protein as a G-quadruplex DNA- and RNA-binding protein ppt

Tài liệu Báo cáo khoa học: Identification of Ewing’s sarcoma protein as a G-quadruplex DNA- and RNA-binding protein ppt

... Htelo(Fig. S6). These findings indicate the importance of the guanidinium group of the Arg in RGG3 for binding to the G-quadruplex. In conclusion, EWS appears to be a DNA- and RNA-binding protein that ... DNA-binding motif in nucleolin [21–27]. The RGG domain of FMRP, which is an RNA-binding protein involved in nerve cell differentiation,interacts with the G-quartet forming RNA [22–25]. In addition, ... domain, initially identified as a single-stranded RNA-binding motif in hnRNP U, is reportedto be the G-quadruplex RNA-binding motif in the fragile X mental retardation protein (FMRP) and the G-quadruplex...
  • 11
  • 786
  • 0
Tài liệu Báo cáo khoa học: Helicobacter pylori acidic stress response factor HP1286 is a YceI homolog with new binding specificity pdf

Tài liệu Báo cáo khoa học: Helicobacter pylori acidic stress response factor HP1286 is a YceI homolog with new binding specificity pdf

... protein for an extrane-ous ligand.We cannot state that the natural ligand of the H. pylori protein is erucamide, but the shape and sizeof the cavity clearly indicate that inside the protein there ... starting from the model of the polyisoprenoid-binding protein from T. thermophilus (Protein Data Bank ID: 1WUB [18]). Refinement was con-tinued using the simulated annealing procedure contained in cns ... belongs to the YceI-like protein family, which in turn is characterized by the lipocalin fold. The latter characterizes proteins possessing an internal cavity with the function ofbinding and or...
  • 10
  • 768
  • 0
Báo cáo khoa học: MicroRNA-373, a new regulator of protein phosphatase 6, functions as an oncogene in hepatocellular carcinoma pdf

Báo cáo khoa học: MicroRNA-373, a new regulator of protein phosphatase 6, functions as an oncogene in hepatocellular carcinoma pdf

... on the intensity of EGFP fluorescencefrom the vector containing mutations in the regionencoding the miR-373 binding sites. These resultsshow that miR-373 binds directly to the 3¢-UTR of the ... on the cell cycle (Fig. 6E).Knockdown of PPP6C resulted in a significantdecrease in the proportion of cells in G1-phase and anincrease in the proportion of cells in S-phase. Thesefindings indicate ... putativebinding site, was inserted downstream of the EGFPcoding region. HepG2 cells were transfected with the reporter vector together with either miR-373 ASOs orpri-373. As shown in Fig. 4B, the intensity...
  • 11
  • 396
  • 0
Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx

Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx

... H2O2-induced apoptosis in transfectedC2C12 cells. Furthermore, there was no direct interac-tion between HSP70 and Smac proteins, and the ATP-binding domain of HSP70, rather than the pep-tide-binding ... indicating that interaction with Smac is notrequired with respect to the role of HSP70 in the inhi-bition of the release of Smac and apoptosis. The role of the ATP-binding domain of HSP70 in ... ofASK1-induced apoptosis in vitro [28]. Furthermore, the ATP-binding domain of HSP70 is critical for sequester-ing AIF in the cytosol [29]. In the present study, wedemonstrated that the ATP-binding...
  • 10
  • 726
  • 0
Tài liệu Báo cáo khoa học: A DExD⁄ H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana docx

Tài liệu Báo cáo khoa học: A DExD⁄ H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana docx

... staining indicated that AtHELPS is mainly expressed in the youngseedlings and vascular tissues of leaves and roots. Using both helps mutants and overexpression lines, we observed that, in the ... calci-neurin B-like proteins, CBL1 and CBL9, were thenidentified as calcium sensors in the differential regula-tion of abiotic stress responses, and in the ABA sig-naling and stress-induced ABA ... IV, V, and VI. The arrow marks the highly conserved residues Asp-Glu-Val-His in motif II. The detailed schemeof the conserved motifs in AtHELPS is shown on the underside. The amino acids in capitals...
  • 11
  • 785
  • 0
Tài liệu Báo cáo khoa học: Functional characterization of an orphan cupin protein from Burkholderia xenovorans reveals a mononuclear nonheme Fe2+-dependent oxygenase that cleaves b-diketones ppt

Tài liệu Báo cáo khoa học: Functional characterization of an orphan cupin protein from Burkholderia xenovorans reveals a mononuclear nonheme Fe2+-dependent oxygenase that cleaves b-diketones ppt

... that has the IMPACT tag fused to the authenticC-terminal Gly145.Expression and purificationRecombinant protein was produced by cultivating the expression strain in shaking flasks containing LB ... ligand binding, and the role ofstorage proteins, the cupins constitute one of the mostdiverse superfamilies of proteins known. They havebeen described from all three domains of life [1,2], and usually ... lead to the identification of fingerprint regions that determinemetal-binding selectivity and catalytic activity (see the recent work on ARD [37]). Within the cupin super-family of proteins, structure-based...
  • 15
  • 624
  • 0
Tài liệu Báo cáo khoa học: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf

Tài liệu Báo cáo khoa học: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf

... detectable in the cytoplasm and nucleus (Fig. 2B). In FITC-labelled hpST3dODN-transfected cells, phospho-STAT3 was detected in the cytoplasm, but not in the nucleus, and ODN wasdetected only in the cytoplasm ... (particularly in whole ani-mals) by impairing the action of STAT1-dependentinterferon. The results obtained in the present study, including the ability of the hairpin decoy STAT3 ODN to inhibit both ... isacting on both STAT3 and STAT1 and that it has the potential to interfere with the biological activity of IFN-c. In the SW480 cell line, IFN-c treatmentresulted in the inhibition of the STAT3-dependentcyclin...
  • 11
  • 558
  • 0
Tài liệu Báo cáo khoa học: Structure of RNase Sa2 complexes with mononucleotides – new aspects of catalytic reaction and substrate recognition pptx

Tài liệu Báo cáo khoa học: Structure of RNase Sa2 complexes with mononucleotides – new aspects of catalytic reaction and substrate recognition pptx

... for the study of protein protein [22] and protein nucleotide recognition [10,23,24], protein folding and stability [25–28], protein dynamics [29], and cytotoxicity[30]. The mechanism of the ... a guanine as the leading base, were docked into the active site of the enzyme. In the five best-dockeddinucleotides in each protein molecule, the position of the guanine base and most of the phosphate ... of all the bases, up tofive, and had the best fit into the base-binding site. In addition, guanine underwent a stacking interactionwith Phe39 and interacted with Arg42. Guanine forms the most...
  • 13
  • 523
  • 0
Tài liệu Báo cáo khoa học: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area ppt

Tài liệu Báo cáo khoa học: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area ppt

... foundto bind tightly to LPL in the vicinity of the active site and also to inhibit the enzymatic activity [12]. Simi-larly, we show here that bis-ANS inhibits the lipase activity of HSL. Interestingly, ... phos-phorylation. This gain in hydrophobic surface areapresumably accounts for the increase in in vitro activity of HSL following PKA phosphorylation throughincreased binding between HSL and the lipid substrateemulsion. ... determine whether the phosphorylation-induced gain in hydrophobicsurface area described here affects other propertiesof HSL than binding to lipids, e.g. binding to lipiddroplet-associated proteins.In...
  • 11
  • 562
  • 0
Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf

Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf

... than the activity in control joints. The ubiquitinated protein lev-els in synovial fluid from osteoarthritic joints werehigher than in the control joint group (Fig. 2A). Wealso examined TRAIL protein ... joints was increased com-pared with that in control joints. Changes in TRAIL and ubiquitin levels may be linked to the progressionof in ammation and may be detected in the synovialfluid. These ... inducedproteasome inhibition in canine chondrocytes. In the absence of ALLN, smears of ubiquitinated proteinswere not observed in control and TRAIL-treatedcanine chondrocytes. In the presence of...
  • 11
  • 461
  • 0

Xem thêm

Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnBáo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP