... for the study of protein protein [22] and protein nucleotide recognition [10,23,24], protein folding and stability [25–28], protein dynamics [29], and cytotoxicity[30]. The mechanism of the ... a guanine as the leading base, were docked into the active site of the enzyme. In the five best-dockeddinucleotides in each protein molecule, the position of the guanine base and most of the phosphate ... of all the bases, up tofive, and had the best fit into the base-binding site. In addition, guanine underwent a stacking interactionwith Phe39 and interacted with Arg42. Guanine forms the most...