... raises the question Ôhow do the a-conotoxins bind to the different nAChR subtypes?Õ,asthey are of intermediate size.a-Conotoxin docking modes on neuronalnAChRsa-Conotoxin binding sites Of the ... ACh binding site (and the dockingsimulation of ligands) because loop C of the b subunitis not involved in the competitive binding site [16]. Finally, the important residues for the binding of ... two of them. With the exception of K183, which is on the b9b10 hairpin, I186 and T57 are in, or close to, the ACh binding site. In this view, the MIIbinding site resembles the PnIB binding site.The...