... expected, ablation of the DNA- binding activity within the N-terminal fragment of Cfp1 (amino acids 1–367, C169A), disruption of the Setd1A interaction with the C-terminal fragment of Cfp1 (amino ... restoration of normal levels of Setd1A, indicating that none of these Cfp1 domainsare necessary for this rescue activity (Fig. 3B). Surpris-ingly, expression of either the amino half of Cfp1(amino ... integral com-ponent of only the Setd1A and Setd1B HMT com-plexes [15,16]. The localization of Setd1B in the absence of Cfp1 has not been determined, but the find-ing that the extent of Setd1A mislocalization...