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Báo cáo khoa học: Replacement of helix 1¢ enhances the lipid binding activity of apoE3 N-terminal domain pot

Báo cáo khoa học: Replacement of helix 1¢ enhances the lipid binding activity of apoE3 N-terminal domain pot

Báo cáo khoa học: Replacement of helix enhances the lipid binding activity of apoE3 N-terminal domain pot

... al. apoE3- NT domain lipid binding FEBS Journal 273 (2006) 558–567 ª 2006 The Authors Journal compilation ª 2006 FEBS 567 Replacement of helix enhances the lipid binding activity of apoE3 N-terminal ... wild-type apoE3- NT. The results indicate that amutation at one end of the apoE3- NT four -helix bundle markedly enhan-ces the lipid binding activity of this protein. In the context of lipoproteinassociated ... enhancement in lipid binding activity. ResultsDesign of helix- to-turn apoE3- NTOn the basis of studies with structurally related helix bundle apolipoproteins [15,16], we hypothesized thatresidues...
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Báo cáo khoa học: ˚ cDNA cloning and 1.75 A crystal structure determination of PPL2, an endochitinase and N-acetylglucosaminebinding hemagglutinin from Parkia platycephala seeds potx

Báo cáo khoa học: ˚ cDNA cloning and 1.75 A crystal structure determination of PPL2, an endochitinase and N-acetylglucosaminebinding hemagglutinin from Parkia platycephala seeds potx

... analyses of the chitin -binding domains and the catalytic domain of Brassica juncea chitinaseBjCHI1. Plant Mol Biol 56, 285–298.39 Robertus JD & Monzingo AF (1999) The structure andaction of ... On the other hand, PPL2 is a single -domain protein. Hence,PPL2 may possess at least two carbohydrate -binding sites. One of them probably corresponds to the cata-lytic site, whereas the other ... seedlings. The size of the amplified genomic DNA was identical to that of the cDNA, indicating that the PPL2 gene was devoid of in-trons, as observed for other class III chitinase genes [43]. The complete...
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Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans pptx

Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans pptx

... alog (pH )pKa2), Lim1 is the lower limit of the curve, Lim 2 is the middle limit of the curve and Lim 3 is the upper limit of the curve.Stopped-flow kinetic studies of the oxidativehalf-reaction ... the expected mass of the a subunit to 40 421 Da, which iswithin error of the measured mass of 40 422 Da.Stopped-flow studies of the reductivehalf-reaction of AADHStudies of the reductive half-reaction ... to thatobserved for the native enzyme. The migration of bothsubunits is consistent with the predicted masses of the mature form of the subunits (14 472 and 40 421 Dafor the small and large...
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx

Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx

... at the end of an a-helical region of the HFE a1 domain (V100 and W103A) as being of par-ticular importance for TfR1 interactions [16,17,20]. The effect of HFE binding to TfR1 is to lower the affinity ... HFE, the proximity of the two a helices and the presence of amino acid side chains that project into the groove appear to prevent peptide binding [16]. The a3 region, like its homologous domain ... cells to express either the wild-type or mutant proteins, and incubated the cellsin the presence or absence of tunicamycin. Drugtreatments resulted in the accumulation of forms of the mutant proteins...
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Báo cáo khoa học:

Báo cáo khoa học: "Computational Lexical Semantics, Incrementality, and the So-called Punctuality of Events" potx

... (9), the development of the drinking event can be measured along the subparts of the glass of beer. Each subpart of the incremental theme argument is mapped onto a subpart of the 2 Complementary ... questioned the coherence of the class of achievement verbs, arguing that not all of them are non-durative. As noted above, Vendler identifies punctual events through the conjunction of the (positive) ... associate with the CONST qualia role of chambre such a collection of instances of the movable_phys__obj type, the CONST role describing the meronymic constitution of a type. 502 In fact, the ability...
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Báo cáo khoa học: CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin doc

Báo cáo khoa học: CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin doc

... expected, ablation of the DNA- binding activity within the N-terminal fragment of Cfp1 (amino acids 1–367, C169A), disruption of the Setd1A interaction with the C-terminal fragment of Cfp1 (amino ... restoration of normal levels of Setd1A, indicating that none of these Cfp1 domainsare necessary for this rescue activity (Fig. 3B). Surpris-ingly, expression of either the amino half of Cfp1(amino ... integral com-ponent of only the Setd1A and Setd1B HMT com-plexes [15,16]. The localization of Setd1B in the absence of Cfp1 has not been determined, but the find-ing that the extent of Setd1A mislocalization...
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Báo cáo khoa học: Post-translational modifications in the active site region of methyl-coenzyme M reductase from methanogenic and methanotrophic archaea potx

Báo cáo khoa học: Post-translational modifications in the active site region of methyl-coenzyme M reductase from methanogenic and methanotrophic archaea potx

... B -binding site. Its unmethylated nitrogen atom Ne2 donates the shortest of the three hydrogen bonds of the protein to the phosphate group of coenzyme B. The distance of 2.65 A˚indicates the ... because the genesrequired for the biosynthesis of the nickel cofactor F430[16] and for the post-translational modifications [9] arenot yet known [17,18]. Also, the in vitro reconstitution of active ... the sulfur is transferred into the carboxamidegroup of glycine in the peptide chain remains to beshown.Neither the functions of the five modifications norwhether the modifications are present...
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Báo cáo khoa học: Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L pdf

Báo cáo khoa học: Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L pdf

... of residualenzyme activity was used to determine the inhibitionconstant Kidue to the tight binding of the protease by the inhibitor and the possibility of modification of the inhibitorbytheenzyme[32].Thesedatawerefittedtothetheoreticalequation ... by the progresscurve of the control reaction at pH 5.5 in the absence of testican-1 (A). When cathepsin L activity was assayed nearneutral pH in the presence of testican-1, the loss of activity was ... coreand not affected by the large glycosaminoglycan moieties. The high homology of the testican-1 thyropin domain to the cathepsin L-inhibitory domain of the p41 variant of the MHC invariant chain...
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Báo cáo khoa học: Hydrogen bond residue positioning in the 599–611 loop of thimet oligopeptidase is required for substrate selection pdf

Báo cáo khoa học: Hydrogen bond residue positioning in the 599–611 loop of thimet oligopeptidase is required for substrate selection pdf

... the formation of a closed form of the enzyme in order to be effi-ciently cleaved, whereas other substrates can be effec-tively utilized even by the open form of the enzyme. The possibility of ... for the model.Furthermore, the experimental effects observed forTyr605 and Tyr612 mutants on enzyme activity validate the close proximity of these residues to the substrate in the model. The ... A˚,respectively). The substrate also maintained its relativeposition in the active site during the simulation. Thesedata do not preclude the existence of other possibleconformations further away from the...
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Báo cáo khoa học: Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L docx

Báo cáo khoa học: Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L docx

... suggests that cathepsin K is a new member of the kininase family. Both the kininogenase activity of cathepsin L and/or the kininase activity of cathepsin K maybe favored by the generation of an acidic ... the kininogenase activity occurs after the partial hydrolysis of HMWK (Fig. 1), as reported forcystatin C-bound cathepsin L [37]. The pH-dependentkininogenase activity of cathepsin L over the ... components, which reduces the pH of the pericellular environment of macrophages [20]. This raises the question of the dual behaviour of kininogens complexedwith CP. While concentrations of cystatins C,...
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Từ khóa: cách viết 1 báo cáo khoa họccách làm 1 bài báo cáo khoa họccách trình bày 1 bài báo cáo khoa họcbáo cáo khoa họcbáo cáo khoa học mẫubáo cáo khoa học y họcNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Chiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ