Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt

Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt

Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt

... FEBS 2481 Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions Janne Molnes 1,2,3 , ... E256 and E290) and the S-domain (residues T168 and K169) (Fig. 1B). To identify the contact residues involved in the in...
Ngày tải lên : 30/03/2014, 04:20
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Báo cáo khoa học: Catalytic digestion of human tumor necrosis factor-a by antibody heavy chain pot

Báo cáo khoa học: Catalytic digestion of human tumor necrosis factor-a by antibody heavy chain pot

... on the surface of the hTNF-a protein, enabling easy access to catalytic antibodies. The acces- sibility of the TNF-a molecule to ETNF-6-H to is one of the most important factors in cleaving the ... chains capable of the degradation of urease in Helicobact- er pylori. The catalytic antibody light chain, UA15-L, could suppress the number of bacteria i...
Ngày tải lên : 06/03/2014, 22:21
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Báo cáo khoa học: Catalytic mechanism of the primary human prostaglandin F2asynthase, aldo-keto reductase 1B1 – prostaglandin D2 synthase activity in the absence of NADP(H) pptx

Báo cáo khoa học: Catalytic mechanism of the primary human prostaglandin F2asynthase, aldo-keto reductase 1B1 – prostaglandin D2 synthase activity in the absence of NADP(H) pptx

... & Penning TM (1996) Character- ization of the substrate binding site in rat liver 3alpha- hydroxysteroid ⁄ dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluores- cence. ... core in this family [ 3–6 ]. To iden- tify the catalytic residues involved in the PGDS and PGFS activity catalyzed by AKR1B1, we introduced sit...
Ngày tải lên : 14/03/2014, 23:20
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Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf

Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf

... in catalysis and the specific involvement of the catalytic residues in the enzymatic reaction. The two zinc ions in the active metal center are thought to participate in substrate binding by activating the ... the deprotonation of the zinc-bound water to form the nucleophilic hydroxide and less involved in substrate binding; and (c) the...
Ngày tải lên : 19/02/2014, 02:20
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Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx

Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx

... leading to autophosphoryla- tion of tyrosine residues on the cytoplasmic domain of the receptor, thereby creating docking sites for adaptor pro- teins, such as Shc and G rb2. The latter protein ... again after returning to a low level. On the other hand, the s ame phosphorylation of EGFR by PKC is known to cause decreased EGFR tyrosine kinase activity, its binding...
Ngày tải lên : 19/02/2014, 16:20
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt

Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt

... receptor Toll and thereby initiates a cyto- plasmic signaling pathway, resulting in the release of a rel family transcription factor Dorsal from the inhibi- tor protein Cactus to activate genes involved ... perform immune functions. This mechanism leads to activation of phenoloxidase, which oxidizes catechols, leading to the formation of toxic quinones and melanin...
Ngày tải lên : 06/03/2014, 09:22
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Báo cáo khoa học: Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids docx

Báo cáo khoa học: Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids docx

... characteristic of the fasting state. The inclusion of fatty acids resulted in increased activities of the a-1 or the a-2 isoforms of AMP- activated protein kinase (AMPK), increased phosphoryla- tion of acetyl-CoA ... mechanism. The finding that epinephrine totally blocked the activation of AMPK by palmitate is of note and requires further investigation of t...
Ngày tải lên : 07/03/2014, 15:20
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Báo cáo khoa học: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-a pdf

Báo cáo khoa học: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-a pdf

... throughout the brain, and is involved in the regulation of energy balance by stimulating increased food intake. Pep- tide YY (PYY) is produced by the gastrointestinal tract, and, via NPY receptor binding, ... of natural substrates is poorly characterized. Identifying substrates is a crucial step in gaining insights into the precise functions of proteases and thei...
Ngày tải lên : 14/03/2014, 23:20
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Báo cáo khoa học: Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells pdf

Báo cáo khoa học: Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells pdf

... responses, the significance of ERK signaling in terms of regulating miRNA expression is of great interest. To study the role of the ERK1 ⁄ 2 pathway in the regulation of miRNA expression, we first determined the ... ERK1 ⁄ 2 activation (Fig. 4B). We also confirmed inhibition of protein synthesis by monitoring expression of c-Fos protein, which is a Fig. 2. Acti...
Ngày tải lên : 16/03/2014, 01:20
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Báo cáo khoa học: Catalytic residues Lys197 and Arg199 ofBacillus subtilis phosphoribosyl diphosphate synthase Alanine-scanning mutagenesis of the flexible catalytic loop ppt

Báo cáo khoa học: Catalytic residues Lys197 and Arg199 ofBacillus subtilis phosphoribosyl diphosphate synthase Alanine-scanning mutagenesis of the flexible catalytic loop ppt

... respect to ATP and noncom- petitive inhibitors with respect to Rib5P. These results indicate that binding of the substrates is ordered with initial binding of ATP followed by binding of Rib5P. In ... ordered binding of the substrates with ATP binding first and a random release of the products [16]. Discussion The kinetic analysis of the K197A and R...
Ngày tải lên : 23/03/2014, 15:20
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